Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises
Recruitment status was Not yet recruiting
The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .|
|Study Start Date:||May 2008|
Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00660465
|Contact: Alexander Gersten, Ph.Dfirstname.lastname@example.org|
|Department of Diagnostic Imaging ;Soroka Univrsity Medical Center||Recruiting|
|Beer Sheva, Israel, 84101|
|Contact: Ilan Shelef, M.D +972-8-6403950 email@example.com|
|Sub-Investigator: Alexander Gersten, Ph.D|
|Sub-Investigator: Batel Lasry|
|Study Director:||Ilan Shelef, M.D||Head, Neuroradiolgy Unit ;Department of Diagnostic Imaging ;Soroka Univrsity Medical Center|