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Evaluation of KX2-391 in Patients With Advanced Malignancies

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00658970
Recruitment Status : Completed
First Posted : April 16, 2008
Last Update Posted : June 8, 2011
Sponsor:
Information provided by:
Athenex, Inc.

Brief Summary:
The purpose of this Phase 1 study is to determine the safety and tolerability of KX2-391 in cancer patients.

Condition or disease Intervention/treatment Phase
Solid Tumors Lymphoma Drug: KX2-391 Phase 1

Detailed Description:
The purpose of this first in human study is to determine the safety and pharmacokinetics of KX2-391 in patients with solid tumors and lymphoma, who are refractory to conventional cancer treatments. In addition, pharmacodynamics will be evaluated using biomarkers in peripheral blood mononuclear cells and in tissue biopsy samples.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 50 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Combined Rising Single-dose (RSD) and Rising Multiple-dose (RMD)Phase 1 Study to Evaluate Safety, Tolerability and Pharmacokinetics of KX2-391 in Patients With Advanced Malignancies That Are Refractory to Conventional Therapies
Study Start Date : November 2007
Actual Primary Completion Date : March 2010
Actual Study Completion Date : May 2011

Resource links provided by the National Library of Medicine



Intervention Details:
  • Drug: KX2-391
    2 mg (starting dose)rising dose, oral dosing, twice daily, 21 day cycle(s); until progression or unacceptable toxicity develops


Primary Outcome Measures :
  1. Determine maximum tolerated dose of the drug [ Time Frame: 64 days ]

Secondary Outcome Measures :
  1. Pharmacokinetics, Pharmacodynamics, Efficacy [ Time Frame: 64 days ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Signed written informed consent
  • Adults over age 18 years of age
  • Confirmed advanced solid tumor or lymphoma that may be metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective; patients with treated brain or ocular metastases are also eligible
  • ECOG performance status of 0-2
  • Life expectancy of at least 14 weeks
  • Adequate bone marrow reserve
  • Adequate liver function as demonstrated by serum bilirubin, alanine aminotransferase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP)
  • Adequate renal function (serum creatinine </= 1.5 x ULN or calculated creatinine clearance > 60 ml/min)
  • Normal coagulation profile (PT/INR and aPTT within institutional normal limits) for those who give consent to tumor biopsy, within 1 week prior to the procedure.
  • Negative pregnancy test for females at Screening, preferably done within 1 week before Day 1 of dosing (not applicable to patients with bilateral oophorectomy and/or hysterectomy)
  • Willing to abstain from sexual activity or practice physical barrier contraception 28 days before Day 1 of dosing and 6 months after the last dose for the patient
  • Signed written informed consent for tumor biopsy for the additional 10 subjects that will be dosed at the MTD and who have accessible tumors

Exclusion Criteria:

  • Unresolved toxicity of higher than Grade 1 severity from previous anti-cancer treatment or investigational agents
  • Receiving or having received investigational agents or systemic anti-cancer agents within 14 days of Day 1 of dosing or 28 days for those agents with unknown elimination half-lives or half-lives of greater than 50 hours
  • Received extensive radiation therapy including sternum, pelvis, scapulae, vertebrae or skull, </= 4 weeks or low dose palliative radiation therapy limited to limbs </= 1 week prior to starting study drug, or who have not recovered from side effects of such therapy
  • Currently taking hormones (i.e., estrogen contraceptives, hormone replacement, anti-estrogen), anti-platelet agents or anti-coagulants, e.g. coumadin, except for those who are on prophylactic doses of anti-coagulants for indwelling venous catheters
  • Use of strong inhibitors or inducers of cytochrome P450 3A4 enzymes 2 weeks or 5 half-lives prior to Day 1 of dosing and during the study (refer to Appendix 3)
  • Pregnant or breast-feeding
  • Major surgery within 4 weeks prior to Day 1 of dosing
  • Major surgery to the upper gastrointestinal tract, or inflammatory bowel disease, malabsorption syndrome or other medical condition that may interfere with oral absorption
  • Signs or symptoms of end organ failure, major chronic illnesses other than cancer, or any severe concomitant conditions which, in the opinion of the investigator, makes it undesirable for the subject to participate in the study or which could jeopardize compliance with the protocol
  • History of angina pectoris, coronary artery disease or cerebrovascular accident, transient ischemic attack or cardiac arrhythmia requiring medical therapy
  • Evidence of hepatitis B or C, human immunodeficiency (HIV) infection, coagulation disorders, or hemolytic conditions, e.g. sickle cell anemia

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00658970


Locations
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United States, Pennsylvania
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
United States, Texas
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Sponsors and Collaborators
Athenex, Inc.
Investigators
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Principal Investigator: Aung Naing, M.D. M.D. Anderson Cancer Center
Principal Investigator: Roger B Cohen, M.D. Fox Chase Cancer Center

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Responsible Party: Allen Barnett/Chief Executivew Officer, Kinex Pharmaceuticals
ClinicalTrials.gov Identifier: NCT00658970     History of Changes
Other Study ID Numbers: KX01-01-07
First Posted: April 16, 2008    Key Record Dates
Last Update Posted: June 8, 2011
Last Verified: June 2011
Keywords provided by Athenex, Inc.:
Open label
Dose escalation
Additional relevant MeSH terms:
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Neoplasms