System-IGF-1 Pathway and Alzheimer's Disease (SIGAL)
|ClinicalTrials.gov Identifier: NCT00647478|
Recruitment Status : Completed
First Posted : March 31, 2008
Last Update Posted : June 6, 2013
|Condition or disease|
|Alzheimer's Disease Mild Cognitive Impairment Cognitive Function 1, Social Control With Normal Activities of Daily Living.|
AD is the most common cause of dementia. During aging, decline of biological brain functions due to a number of genetic and environmental factors facilitates the onset of AD. MCI includes prodromal AD.
The identification of the risk factors for AD must be a priority in order to define the best therapeutic approach.
Recent data support the notion that IGF-I pathway accounts for neuronal protection, with a dual effect, on both brain Aβ peptide and tau protein.
This large, multicenter, prospective, observational, cross-sectional population-based study in 3 parallel groups (200 participants per group) is aimed to assess differences between IGF-I and IGFBP3 circulating levels and polymorphisms in AD patients and control elderly subjects, and in MCI patients.
|Study Type :||Observational|
|Actual Enrollment :||693 participants|
|Official Title:||A Multicenter Study to Assess Differences Between Circulating Levels of IGF-I and IGFBP-3 in Patients With Sporadic Late-onset Alzheimer's Disease and Control Elderly Subjects.|
|Study Start Date :||October 2007|
|Primary Completion Date :||October 2010|
|Study Completion Date :||July 2012|
Control elderly subjects with normal cognitive function
- Circulating IGF-I and IGFBP-3 levels in AD patients and control elderly subjects at the time of assessment(T0). [ Time Frame: 24 hours ]
- Circulating IGF-I and IGFBP-3 levels [ Time Frame: 24 hours ]
- Genetic polymorphisms in IGF-I / IGFBP-3 [ Time Frame: 24 hours ]
- Circulating IGF-I and IGFBP-3 levels and genetic polymorphisms in IGF-I / IGFBP-3 according to cognitive function. [ Time Frame: 24 hours ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00647478
|Broca Hospital Memory Clinic (CMRR)|
|Paris, France, 75013|
|Principal Investigator:||Olivier Hanon, MD, PhD||Assistance Publique - Hôpitaux de Paris|