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Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

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ClinicalTrials.gov Identifier: NCT00630071
Recruitment Status : Completed
First Posted : March 6, 2008
Last Update Posted : October 16, 2012
Sponsor:
Information provided by (Responsible Party):
Michael Sand, Ruhr University of Bochum

Brief Summary:
The values of laboratory examinations which are useful for the diagnoses of acute appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR). Another laboratory value which has recently received considerable attention for the early diagnosis of bacterial infection and sepsis is pro-calcitonin (PCT). In recent studies it has been clearly shown that PCT is one of the most important biochemical indicators which closely correlates with the severity of inflammatory host response to microbial infections. Aim of this open, prospective study is therefore to investigate if PCT has an accurate diagnostic value for the diagnosis of acute appendicitis.

Condition or disease
Appendicitis

Study Type : Observational
Actual Enrollment : 103 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Study Investigating the Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis
Study Start Date : February 2008
Actual Study Completion Date : August 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Appendicitis
U.S. FDA Resources




Biospecimen Retention:   Samples With DNA
1.5 ml whole blood


Information from the National Library of Medicine

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Ages Eligible for Study:   14 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Surgical Emergency Room
Criteria

Inclusion Criteria:

  • Clinical diagnosis of appendicitis

Exclusion Criteria:

  • Antibiotic therapy
  • Infection at other body sites
  • Age < 14 years
  • Appendectomy in the medical history

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00630071


Locations
Germany
Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany
Bochum, Germany, 44791
Sponsors and Collaborators
Ruhr University of Bochum
Investigators
Study Chair: Benno Mann, PD Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
Principal Investigator: Michael Sand, Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum

Publications of Results:
Responsible Party: Michael Sand, Dr., Ruhr University of Bochum
ClinicalTrials.gov Identifier: NCT00630071     History of Changes
Other Study ID Numbers: PCT 01
First Posted: March 6, 2008    Key Record Dates
Last Update Posted: October 16, 2012
Last Verified: October 2012

Keywords provided by Michael Sand, Ruhr University of Bochum:
Diagnostic Appendicitis
Procalcitonin

Additional relevant MeSH terms:
Appendicitis
Intraabdominal Infections
Infection
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Cecal Diseases
Intestinal Diseases
Calcitonin
Bone Density Conservation Agents
Physiological Effects of Drugs