The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
|ClinicalTrials.gov Identifier: NCT00627068|
Recruitment Status : Completed
First Posted : February 29, 2008
Last Update Posted : September 20, 2011
|Condition or disease|
To determine if a correlation exists between EPC function and eNOS-dependent NO production in EPCs from populations with high versus low cardiovascular risk:
- High and low cardiovascular risk subjects will be identified based on age or history of cardiovascular disease. Endothelial function will be measured by ultrasound.
- EPCs will be isolated from peripheral blood of these subjects. EPC function will be assessed by measuring adhesion to endothelium, migration, proliferation, and differentiation, and compared to their expression and activity of eNOS.
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function|
|Study Start Date :||July 2007|
|Actual Primary Completion Date :||December 2010|
|Actual Study Completion Date :||December 2010|
High cardiovascular risk age over 61 years.
Low Cardiovascular risk age over 61.
High cardiovascular risk age over 25 but under 61.
Low cardiovascular risk age over 25 under 61.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00627068
|United States, California|
|UCSF, Department of Cardiology|
|San Francisco, California, United States, 94143|
|Principal Investigator:||Yerem Yeghiazarians, M.D||University of California, San Francisco|