Stress and Marijuana Cue-elicited Craving and Reactivity
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ClinicalTrials.gov Identifier: NCT00613405 |
Recruitment Status :
Completed
First Posted : February 13, 2008
Results First Posted : May 4, 2012
Last Update Posted : April 30, 2013
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Condition or disease | Intervention/treatment | Phase |
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Cannabis Use Disorders | Other: Stress + cue exposure Other: No stress + cue exposure | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 87 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Official Title: | Stress and Marijuana Cue-elicited Craving and Reactivity |
Study Start Date : | January 2008 |
Actual Primary Completion Date : | May 2009 |
Actual Study Completion Date : | May 2009 |
Arm | Intervention/treatment |
---|---|
Experimental: Stress + cue exposure
Individuals were exposed to the Trier Social Stress Test (TSST) as well as neutral cues and marijana cues.
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Other: Stress + cue exposure
Trier Social Stress Task(TSST): subject is asked to give a talk and perform a math task in front of an audience, follwed by neutral and marijuana cue exposure.
Other Name: Stress stask, TSST |
Experimental: No stress + cue exposure
Individuals were not exposed to a stress test, but were exposed to neutral cues and marijuana cues.
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Other: No stress + cue exposure
Neutral and marijuana-associated cue exposure (scripted imagery, in vivo cues).
Other Name: marijuana cue exposure, neutral cue exposure |
- Subjective Craving of Marijuana [ Time Frame: approx 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues). ]Defined as the score on the Marijuana Craving Questionnaire (MCQ), range 7-84, higher scores indicate more craving
- Physiological Assessments: Serum Cortisol, ACTH, BP, HR, and GSR [ Time Frame: ~ 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues). ]
- Feelings of Stress/Anxiety as Measured by the State-Trait Inventory (STAI) [ Time Frame: ~2 hours ]
- Current Mood as Assessed by the Mood Form [ Time Frame: ~2 hours ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Meets Diagnostic and Statistical Methods (DSM)-IV Criteria for Marijuana Dependence
- Between the ages of 18 and 65
- Must abstain from marijuana use the day of testing and other drug use three days prior to testing
Exclusion Criteria:
- Must not be taking any psychoactive medication, or medication that alters the hypothalamic pituitary adrenal (HPA) Axis functioning
- Must not be taking any medications that alter heart rate or skin conductance monitoring
- Cannot meet criteria for current major Axis I disorder (may alter response to stress)
- Cannot be morbidly obese (Body Mass Index >39)
- Cannot meet current abuse or dependence criteria of other substances in past 90 days
- Must not have a medical condition that impacts HPA functioning (Hypertension, chronic pain, Addison's disease)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00613405
United States, South Carolina | |
Medical University of South Carolina | |
Charleston, South Carolina, United States, 29425 |
Principal Investigator: | Aimee L McRae, PharmD, BCPP | Medical University of South Carolina |
Responsible Party: | Aimee McRae-Clark, Associate Professor of Psychiatry, Medical University of South Carolina |
ClinicalTrials.gov Identifier: | NCT00613405 History of Changes |
Other Study ID Numbers: |
HR#17195 R21DA022424 ( U.S. NIH Grant/Contract ) R21DA022424-01A1 ( U.S. NIH Grant/Contract ) |
First Posted: | February 13, 2008 Key Record Dates |
Results First Posted: | May 4, 2012 |
Last Update Posted: | April 30, 2013 |
Last Verified: | April 2013 |
substance-related disorders |
Marijuana Abuse Substance-Related Disorders Chemically-Induced Disorders Mental Disorders |