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Exploring the Role of 3T MRI in Gamma Knife Radiosurgery

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00602992
Recruitment Status : Completed
First Posted : January 28, 2008
Last Update Posted : June 23, 2016
Information provided by (Responsible Party):
University Health Network, Toronto

Brief Summary:
Gamma Knife radiosurgery is a non-invasive technique for the delivery of a single, high dose of radiation to an intra-cranial target. MRI has an established and central role in the treatment planning process and assessment of response to intracranial radiosurgery. Increasing the field strength of MRI from 1.5T to 3T promises to improve the signal, and in turn the quality of images. However, the technology also introduces new limitations, and the role and safety of 3T MRI in the management of patients receiving radiosurgery has not yet been reported. In this pilot study, we will explore the spatial integrity, and incremental image-guidance utility of 3T MRI in patients receiving radiosurgery. The preliminary data acquired in this study will be instrumental to the judicious design and conduct of subsequent definitive clinical trials. Up to fifty patients will be enrolled in this study.

Condition or disease
Brain Metastases

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Study Type : Observational
Actual Enrollment : 45 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Exploring the Role of 3T MRI in Gamma Knife Radiosurgery: A Pilot Study
Study Start Date : August 2006
Actual Primary Completion Date : December 2008
Actual Study Completion Date : December 2008

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients who have consented to Gamma Knife radiosurgery.

Inclusion Criteria:

  • Patients planned to receive Gamma Knife radiosurgery will be eligible for enrollment on this study.

Exclusion Criteria:

  • Age<18
  • Contra-indications to 3T MRI, such as implanted metal devices or shrapnel.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00602992

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Canada, Ontario
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Sponsors and Collaborators
University Health Network, Toronto
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Principal Investigator: Cynthia Menard, MD University Health Network, Toronto

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Responsible Party: University Health Network, Toronto Identifier: NCT00602992     History of Changes
Other Study ID Numbers: 06-0427-CE
First Posted: January 28, 2008    Key Record Dates
Last Update Posted: June 23, 2016
Last Verified: June 2016

Keywords provided by University Health Network, Toronto:
Gamma Knife Radiosurgery