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Circulation Improving Resuscitation Care (CIRC) (CIRC)

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ClinicalTrials.gov Identifier: NCT00597207
Recruitment Status : Completed
First Posted : January 17, 2008
Results First Posted : April 14, 2014
Last Update Posted : July 24, 2018
Ullevaal University Hospital
Information provided by (Responsible Party):
Zoll Medical Corporation

Brief Summary:
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.

Condition or disease Intervention/treatment Phase
Cardiac Arrest Cardiopulmonary Resuscitation Device: AutoPulse Other: Manual Not Applicable

Detailed Description:
Sudden out-of-hospital cardiac arrest (OOH-CA) remains a significant cause of death, in spite of recent declines in overall mortality from cardiovascular disease. Several studies document sub optimal quality of manual chest compressions and this may influence outcome. However, studies comparing manual and mechanical chest compressions have resulted in conflicted results. The investigators think this may be based on methodology and design issues of the trials as much as not focusing on training and experience in operating a mechanical device clinically. Therefore the investigators will focus on these issues and implement three phases in the study (In field training, Run In phase, and Study phase). The investigators will also focus on early use of mechanical CPR after arrival at patient side and randomization at arrival. In order to achieve this the investigators will follow the Norwegian CPR Guidelines with 3 min CPR before defibrillation and the 3 min algorithm. Quality of CPR will be monitored.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 4231 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized Controlled Study Comparing Autopulse To Manual CPR In A CPR-First Protocol For Out-Of-Hospital Cardiac Arrest
Study Start Date : January 2008
Actual Primary Completion Date : February 2011
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1
Mechanical CPR with AutoPulse
Device: AutoPulse
Mechanical device that provides chest compression

Manual CPR
Other: Manual
Manual chest compression

Primary Outcome Measures :
  1. Hospital Discharge [ Time Frame: From time of first contact until hospital discharge, up to 90 days. ]
    Whether a subject was discharged alive from the hospital or alternatively died prior to discharge.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patents aged 18 years (or local age of consent) or more who suffer non-traumatic arrest of presumed cardiac etiology in an out-of-hospital setting and who do not meet any of the exclusion criteria below.

Exclusion Criteria:

  • Traumatic arrest (blunt, penetrating, burns)
  • Arrest due to exsanguinations, strangulation, smoke inhalation, drug overdose, electrocution, hanging, drowning.
  • Known or clinically apparent pregnancy
  • Do Not Attempt to Resuscitate (DNAR) orders
  • Apparent patient weight more than 225 kg (500 lbs)
  • Wards of the state
  • Prisoner
  • CPR device other than AutoPulse
  • Patients who are reached after 16 minutes after the time of emergency call (911). This exclusion is determined at the time of CRF abstraction, not during treatment of the patient.

    • If patient is unaccompanied, or accompanied by a person or persons unfamiliar with their his-tory, determination of these exclusion criteria will, perforce, be left to the best estimation of the rescue personnel. At no time, should an attempt to determine these criteria be allowed to delay the administration of life-saving treatment.

      • These criteria will be determined in the best estimation of the rescue personnel, or if the AutoPulse signals that the patient is outside the parameters for AutoPulse deployment.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00597207

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United States, Florida
Hillsborough Fire Rescue
Tampa, Florida, United States, 33610
United States, Texas
Houston Fire
Houston, Texas, United States, 77002
United States, Wisconsin
Gold Cross EMS
Menasha, Wisconsin, United States, 54952
Vienna EMS
Vienna, Austria
Nijmegen EMS
Nijmegen, Netherlands
Sponsors and Collaborators
Zoll Medical Corporation
Ullevaal University Hospital
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Principal Investigator: Lars Wik, MD Ullevaal University Hospital
Principal Investigator: David Persse, MD Houston Fire
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Zoll Medical Corporation
ClinicalTrials.gov Identifier: NCT00597207    
Other Study ID Numbers: Zoll-0100
First Posted: January 17, 2008    Key Record Dates
Results First Posted: April 14, 2014
Last Update Posted: July 24, 2018
Last Verified: June 2018
Keywords provided by Zoll Medical Corporation:
Additional relevant MeSH terms:
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Heart Arrest
Heart Diseases
Cardiovascular Diseases