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Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00594711
Recruitment Status : Completed
First Posted : January 16, 2008
Last Update Posted : October 31, 2011
University of Eastern Finland
Information provided by (Responsible Party):
Taru Grohn, Kuopio University Hospital

Brief Summary:

Outcome of psychodynamic psychotherapy measured by [123I] nor-B-CIT SPET imaging

Background Psychodynamic psychotherapy is a widely practised form of psychotherapy in the treatment of depression. There is evidence that serotonin transporter (SERT) densities are altered in depression. Preliminary observations have suggested that SERT function may recover in connection with dynamic psychotherapy.

The objective was to determine whether SERT densities change in relation to clinical recovery during psychodynamic psychotherapy.

Condition or disease

Detailed Description:


Method Twenty six drug-naïve currently depressed (moderate/severe) patients with no previous treatment were recruited for the study. The baseline study included a group of 18 healthy controls. The patients were randomised into psychotherapy and waiting-list control groups. For controls, psychotherapy was started after a 6-month waiting period. [123I] nor-B-CIT SPET imaging was performed at baseline and after 12 months of psychotherapy. For the controls, additional imaging was performed after the 6-month waiting period.

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Study Type : Observational
Actual Enrollment : 26 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : January 2000
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine


Biospecimen Retention:   Samples With DNA
DNA, creatine, B-vitamin,BP from blood samples.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patiens of clinic

Inclusion Criteria:

  • depression

Exclusion Criteria:

  • antidepressive medication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00594711

Sponsors and Collaborators
Kuopio University Hospital
University of Eastern Finland
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Principal Investigator: Pirjo Saarinen, Ph.D. Kuopio University Hospital
Study Director: Johannes Lehtonen, Ph.D Kuopio University Hospital
Study Chair: Lehto Soili, MD Kuopio University Hospital
Study Chair: Minna Valkonen-Korhonen, Ph.D Kuopio University
Study Chair: Pasi Ahola, MD Kuopio University
Study Chair: Mikko Joensuu, MD Kuopio University Hospital
Study Chair: Tommi Tolmunen, Ph.D. Kuopio University Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Taru Grohn, Pirjo Saarinen, Kuopio University Hospital Identifier: NCT00594711     History of Changes
Other Study ID Numbers: KUH5703410
First Posted: January 16, 2008    Key Record Dates
Last Update Posted: October 31, 2011
Last Verified: October 2011

Keywords provided by Taru Grohn, Kuopio University Hospital:

Additional relevant MeSH terms:
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Behavioral Symptoms