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ClinicalTrials.gov Identifier: NCT00590512
Recruitment Status :
First Posted : January 10, 2008
Last Update Posted : August 29, 2013
Brigham and Women's Hospital
Information provided by (Responsible Party):
Rhonda Bentley-Lewis, MD, Brigham and Women's Hospital
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 35 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Healthy male, African-American volunteers
18-35 years of age,
No personal or first degree relative with hypertension or diabetes,
Blood pressure <130/85 mmHg and > 90/60 at the screening visit,
Body mass index <30 kg/m2,
No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram).
Alcohol intake >2 beverage/night,
Recreational drug use,
Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months,
Prescription or herbal medication use,
Ischemic changes on resting electrocardiogram,
Known hypersensitivity to any of the study drugs,
Other active medical problems detected by examination or laboratory testing.