Peripheral Blood and/or Bone Marrow, Including Detection of Occult Metastases, in Patients With Melanoma
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The purpose of this study is to determine if tumor cells can be detected in the peripheral blood and/or bone marrow of patients with melanoma.
Condition or disease
Patients with melanoma can succumb to subclinical metastatic disease, not detectable at presentation by conventional physical examination, hematologic and biochemical screening, or radiologic evaluation. More intensive radiologic evaluation with CT or radioisotope scanning has not proven to be useful. What may be useful is a more sensitive method of staging melanoma patients at presentation, specifically evaluating them for subclinical systemic disease.
Assess the sensitivity of RT-PCR to detect evidence of melanoma cells in bone marrow and/or peripheral blood and estimate sensitivity separately for each of the different stage groupings for melanoma [ Time Frame: 2 years ]
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Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Melanoma Patients seen at Memorial Sloan-Kettering Cancer Center (MSK)
MSK Patients with histologically confirmed melanoma of any site and at least one of the following:
Primary tumor > 4.0 mm thick (AJCC Stage IIB)
Clinically or histologically positive regional nodes (AJCC Stage III)