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ClinicalTrials.gov Identifier: NCT00581321
Active, not recruiting
: December 27, 2007
Last Update Posted
: January 26, 2018
Satish R. Raj
National Center for Research Resources (NCRR)
Information provided by (Responsible Party):
Satish R. Raj, Vanderbilt University Medical Center
In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.
Condition or disease
Blood PressureCardiac Transplantation
Dietary Supplement: water
In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. We will test the hypothesis that water ingestion will increase the systemic vascular resistance. This study will occur in patients status post cardiac transplantation during their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs and plasma norepinephrine levels will be measured before and 30 min after the water ingestion.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
s/p cardiac transplantation scheduled for clinical right heart catheterization
age > 18 years
significant tricuspid regurgitation
inability to safely swallow 500 ml of water
other major medical comorbidities such as advanced renal disease where water ingestion may be harmful to patient