Treatment for Adolescent Marijuana Abuse
Marijuana remains the most prevalent illicit substance used by adolescents and the number of adolescents receiving treatment for marijuana abuse more than tripled during the last decade. A small number of clinical trials suggest that family-based and individual interventions have efficacy for treating adolescent substance abuse. However, even with these interventions most adolescents fail to reduce their substance use substantially, thus, there remains much room for improvement of treatment services. The overarching goal of this project is to develop and test novel behavioral treatments to enhance treatment outcome in this important treatment population, and in so doing, learn more about mechanisms of change that have broader implications for addiction science. In our initial Stage IB project "Behavioral Treatment for Adolescent Marijuana Abuse", we created, manualized, and pilot tested a unique contingency-management (CM) intervention that combined abstinence-based voucher incentives with contingency management training for parents. A small randomized, clinical trial provided encouraging results. When added to a commonly used cognitive-behavior therapy, CM improved rates of sustained abstinence during treatment. Adolescents receiving this intervention were less likely to relapse over the 9-month follow-up period, however this finding was not as robust as the observed during treatment effects, most likely due to the small sample size and associated low power to detect effects. Despite strong indicators of the efficacy of this CM intervention, there remained room for improvement in increasing rates of treatment response and reducing rates of relapse. Hypothesized mediators and moderators of change indicated that changes in parenting had direct effects on post-treatment marijuana abstinence outcomes, and that abstinence early in treatment was a robust predictor of the CM treatment effect. This proposal will systematically replicate and extend these findings. A Stage II trial will compare three treatment conditions: (1) cognitive behavior therapy (CBT only); (2) CBT plus CM; and (3) CBT plus an enhanced CM model targeting increased early abstinence rates, parenting skills, and maintenance of effects. Replicating the initial demonstration of the positive effects of CM will extend the scientific evidence for use of CM to increase treatment efficacy for substance-abusing adolescents. Testing an enhanced CM model will determine if modifications that are consistent with the underlying behavioral principles and empiricism supporting CM interventions can result in improved outcomes. Last, assessment of potential mechanisms of action, particularly parenting, adolescent psychopathology and impulsivity, will provide scientific information directly relevant to future development of more effective intervention and prevention models of adolescent substance abuse, and will inform us about fundamental mechanisms operating in drug-dependence.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Behavioral Treatment of Adolescent Marijuana Use|
- Marijuana Abstinence (2 Weeks or Greater) [ Time Frame: Testing done twice weekly for 14 weeks. ] [ Designated as safety issue: No ]Percentage of participants who achieved 2 continuous weeks of marijuana abstinence as verified by twice weekly urine testing during the 14 weeks of treatment.
- Marijuana Abstinence (4 Weeks or Greater) [ Time Frame: Twice weekly urine tests for 14 weeks. ] [ Designated as safety issue: No ]Percentage of participants who achieved 4 continuous weeks of marijuana abstinence as verified by twice weekly urine testing during the 14 weeks of treatment.
- Proportion of Days of Marijuana Abstinence Across All Days of Treatment (14 Weeks) [ Time Frame: This is for the proportion of days abstinent across the entire 14-week treatment period. Self-report data are collected twice weekly during treatment to obtain a cumulative proportion ] [ Designated as safety issue: No ]This reflects the mean proportion of days of marijuana abstinence for each participant
|Study Start Date:||November 2007|
|Study Completion Date:||December 2013|
|Primary Completion Date:||July 2012 (Final data collection date for primary outcome measure)|
Integrated psychosocial counseling. 14 weekly session. Twice weekly urine testing. Abstinence-based incentives based on urine test results. 14 weekly behavioral parenting sessions.
Weekly Individual Counseling SessionsBehavioral: CM
Abstinence-based incentives delivered contingent on drug-negative urine test results.Behavioral: BPT
Behavioral parent training involve 14 weekly counseling curriculum to improve parenting skills.
Integrated psychosocial counseling. 14 weekly sessions. Twice weekly urine testing. Abstinence-based incentives based on urine test results.
Weekly Individual Counseling SessionsBehavioral: CM
Abstinence-based incentives delivered contingent on drug-negative urine test results.
Active Comparator: MET/CBT
Integrated psychosocial counseling. 14 weekly sessions.
Weekly Individual Counseling Sessions
Please refer to this study by its ClinicalTrials.gov identifier: NCT00580671
|United States, New Hampshire|
|Geisel School of Medicine at Dartmouth|
|Lebanon, New Hampshire, United States, 03756|
|Principal Investigator:||Alan J Budney, Ph.D.||Geisel School of Medicine at Dartmouth|