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Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Pressure Support Ventilation (PSV), Neurally Adjusted Ventilatory Assist (NAVA) and Controlled by Patient

This study has been completed.
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital Identifier:
First received: December 18, 2007
Last updated: April 27, 2015
Last verified: April 2015
The investigators' aim is to study the effect of pressure support ventilation versus neurally adjusted assist (NAVA) and controlled by patient in mechanically ventilated ALI/ARDS subjects.

Condition Intervention
ALI/ARDS Patients Procedure: PSV Procedure: NAVA Procedure: patient-controlled

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Different Assisted Mechanical Ventilation in ALI/ARDS Patients: PSV, NAVA and Controlled by Patient

Resource links provided by NLM:

Further study details as provided by Davide Chiumello, Policlinico Hospital:

Primary Outcome Measures:
  • Respiratory mechanics work of breathing,end expiratory lung volume, gas exchange, dead space, patient's comfort level [ Time Frame: 30 minutes ]

Enrollment: 15
Study Start Date: August 2013
Study Completion Date: November 2014
Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1

ALI/ARDS patients

evaluated the effect of PSV, NAVA and assisted controlled mechanical ventilation by patient through a button

Procedure: PSV
Pressure Support Ventilation
Procedure: NAVA
Neurally Adjusted Ventilatory Assist
Procedure: patient-controlled
assisted controlled MV through a button

Detailed Description:
In this study, PSV is compared with NAVA and assisted mechanically ventilation controlled by patient through a button. Inclusion criteria are: assisted mechanically ventilated ALI/ARDS patients.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ALI/ARDS patients

Exclusion Criteria:

  • Haemodynamic instability
  • Barotrauma
  • COPD
  Contacts and Locations
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Please refer to this study by its identifier: NCT00576771

Policlinico Hospital
Milan, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Principal Investigator: Davide Chiumello, MD Policlinico Hospital
  More Information

Responsible Party: Davide Chiumello, MD, Policlinico Hospital Identifier: NCT00576771     History of Changes
Other Study ID Numbers: 222222
Study First Received: December 18, 2007
Last Updated: April 27, 2015

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Lung Injury processed this record on August 17, 2017