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Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00564408
Recruitment Status : Completed
First Posted : November 28, 2007
Last Update Posted : August 3, 2009
Information provided by:
Danish Headache Center

Brief Summary:
The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

Condition or disease Intervention/treatment Phase
Headache Drug: Carbachol Not Applicable

Detailed Description:
To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol
Study Start Date : August 2007
Actual Primary Completion Date : October 2008
Actual Study Completion Date : February 2009

Resource links provided by the National Library of Medicine

MedlinePlus Genetics related topics: Migraine
MedlinePlus related topics: Headache
Drug Information available for: Carbachol

Arm Intervention/treatment
Experimental: I Drug: Carbachol
3 microgram per kg bodyweight infused intravenously

Primary Outcome Measures :
  1. Headache response after Carbachol infusion [ Time Frame: 1 day after infusion ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Migraine without aura
  • Weight 50-100 kg

Exclusion Criteria:

  • Other significant diseases
  • Migraine 5 days prior to experiment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00564408

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Danish Headache Center
Glostrup, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
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Principal Investigator: Henrik Schytz, MD Danish Headache Center
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Responsible Party: Henrik Schytz/MD, Danish HC Identifier: NCT00564408    
Other Study ID Numbers: HC20070049
First Posted: November 28, 2007    Key Record Dates
Last Update Posted: August 3, 2009
Last Verified: July 2009
Additional relevant MeSH terms:
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Neurologic Manifestations
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Non-Narcotic
Sensory System Agents
Protective Agents