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Effects of Acetaminophen on Hurt Feelings

This study has been completed.
Information provided by:
University of Toronto Identifier:
First received: November 16, 2007
Last updated: June 23, 2008
Last verified: June 2008
The purpose of the study is to investigate whether ingestion of acetaminophen reduces the experience of hurt feelings.

Condition Intervention
Emotional Pain Drug: acetaminophen Other: cornstarch

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Acetaminophen on Hurt Feelings

Resource links provided by NLM:

Further study details as provided by University of Toronto:

Primary Outcome Measures:
  • Self-reported daily hurt feelings [ Time Frame: 21 days ]

Secondary Outcome Measures:
  • Reports of emotional states other than hurt feelings [ Time Frame: 21 days ]
  • Evaluations of self-worth [ Time Frame: 21 days ]

Enrollment: 60
Study Start Date: November 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
2000 mg acetaminophen per day
Drug: acetaminophen
2 x 1000 mg doses per day
Placebo Comparator: 2
2000 mg cornstarch per day
Other: cornstarch
2 x 1000 mg cornstarch per day


Ages Eligible for Study:   17 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • University of Toronto undergraduate psychology student

Exclusion Criteria:

  • Alcohol consumption (more than 2 drinks per day)
  • Intake of enzyme-inducing drugs
  • Prolonged fasting/eating disorders/gastroenteritis
  • Intake of other over-the-counter or prescription analgesics
  • Liver Disorders
  • History of abuse treatment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00561288

Canada, Ontario
University of Toronto
Toronto, Ontario, Canada, M5S 3G3
Sponsors and Collaborators
University of Toronto
Principal Investigator: Geoff MacDonald, Ph.D. University of Toronto
Principal Investigator: Nathan DeWall, Ph.D. University of Kentucky
  More Information Identifier: NCT00561288     History of Changes
Other Study ID Numbers: 20619
Study First Received: November 16, 2007
Last Updated: June 23, 2008

Keywords provided by University of Toronto:
Social Psychology
Interpersonal Rejection

Additional relevant MeSH terms:
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Antipyretics processed this record on September 21, 2017