Effects of Acetaminophen on Hurt Feelings

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00561288
Recruitment Status : Completed
First Posted : November 20, 2007
Last Update Posted : June 25, 2008
Information provided by:
University of Toronto

Brief Summary:
The purpose of the study is to investigate whether ingestion of acetaminophen reduces the experience of hurt feelings.

Condition or disease Intervention/treatment Phase
Emotional Pain Drug: acetaminophen Other: cornstarch Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Acetaminophen on Hurt Feelings
Study Start Date : November 2007
Actual Primary Completion Date : May 2008
Actual Study Completion Date : May 2008

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: 1
2000 mg acetaminophen per day
Drug: acetaminophen
2 x 1000 mg doses per day

Placebo Comparator: 2
2000 mg cornstarch per day
Other: cornstarch
2 x 1000 mg cornstarch per day

Primary Outcome Measures :
  1. Self-reported daily hurt feelings [ Time Frame: 21 days ]

Secondary Outcome Measures :
  1. Reports of emotional states other than hurt feelings [ Time Frame: 21 days ]
  2. Evaluations of self-worth [ Time Frame: 21 days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • University of Toronto undergraduate psychology student

Exclusion Criteria:

  • Alcohol consumption (more than 2 drinks per day)
  • Intake of enzyme-inducing drugs
  • Prolonged fasting/eating disorders/gastroenteritis
  • Intake of other over-the-counter or prescription analgesics
  • Liver Disorders
  • History of abuse treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00561288

Canada, Ontario
University of Toronto
Toronto, Ontario, Canada, M5S 3G3
Sponsors and Collaborators
University of Toronto
Principal Investigator: Geoff MacDonald, Ph.D. University of Toronto
Principal Investigator: Nathan DeWall, Ph.D. University of Kentucky Identifier: NCT00561288     History of Changes
Other Study ID Numbers: 20619
First Posted: November 20, 2007    Key Record Dates
Last Update Posted: June 25, 2008
Last Verified: June 2008

Keywords provided by University of Toronto:
Social Psychology
Interpersonal Rejection

Additional relevant MeSH terms:
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs