We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu
IMPORTANT: Due to the lapse in government funding, the information on this web site may not be up to date, transactions submitted via the web site may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00546689
Recruitment Status : Completed
First Posted : October 19, 2007
Last Update Posted : April 18, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
Correlation between intestinal parasites and serum level of eosinophils and IgE in individuals with HIV or aids attended at clinical hospital of the Botucatu Medical School-UNESP

Condition or disease
HIV Infections

Detailed Description:
The present study correlates intestinal parasitism and levels of eosonophils and of serum IgEs in patients attended at the C.H. of the School of Medicine - Botucatu/UNESP. Thirty adult patients with AIDS were analyzed in the use of HAART, aged 42 ±11 years, 14 (46.7%) male, excluding those that had used anthelminthics 30 days prior to collection. Socioeconomic questionaires were applied and 3 samples of feces were taken for parasitological exams (TF-test® method) and 5 ml of blood for counting eosinophils (automated hematological counter, Pentra 80, ABX) and IgE doses (equipment BN-100, Dade-Behring). The index of parasites was 10%, with E.nana (3.3%), E.coli (3.3%) and B.hominis (3.3%). Parasitized individuals were from an urban region with complete basic sanitation and good socioeconomic level. Normal eosinphil values were found in all samples and increased IgE values in 1 (33.3%) sample. The index of parasites was low due to good socioeconomic level and disease control. Augmented IgE levels corroborate the literature, which reports an increase characteristic of immune response in the face of parasitic infections in individuals with HIV or AIDS. In conclusion, new studies should be undertaken to evaluate the level of eosinophils associated with cytokines to obtain a better understanding of this correlation.

Study Design

Study Type : Observational
Actual Enrollment : 30 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS
Study Start Date : March 2007
Study Completion Date : August 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: HIV/AIDS
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
1 , 2
those with HIV


Outcome Measures

Primary Outcome Measures :
  1. all [ Time Frame: one year ]

Secondary Outcome Measures :
  1. all [ Time Frame: one year ]

Biospecimen Retention:   Samples Without DNA
Sample of Blood Sample of Feces

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
primary care clinic
Criteria

Inclusion Criteria:

  • HIV or AIDS
  • age same or superior to 18 years,
  • both sexes
  • assisted by the Hospital of the Clinics of Botucatu Medical School-UNESP

Exclusion Criteria:

  • use of anthelminthic in the period of 30 days antecedents the it dates from collection
  • individuals that don't have all of the necessary evaluations to the objectives of the study
  • individuals that abandon the attendance, or that you/they are to death during the study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00546689


Sponsors and Collaborators
UPECLIN HC FM Botucatu Unesp
Investigators
Study Chair: Paulo C Pereira, Phd Botucatu Medical School - UNESP
More Information

ClinicalTrials.gov Identifier: NCT00546689     History of Changes
Other Study ID Numbers: upeclin/HC/FMB-Unesp-02
Botucatu Medical School UNESP
First Posted: October 19, 2007    Key Record Dates
Last Update Posted: April 18, 2008
Last Verified: October 2007

Keywords provided by UPECLIN HC FM Botucatu Unesp:
HIV
aids
intestinal parasites
eosinophils
immunoglobulins
HIV/aids
Treatment Experienced

Additional relevant MeSH terms:
HIV Infections
Intestinal Diseases, Parasitic
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Parasitic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases