Rehabilitation for Patients With Pulmonary Arterial Hypertension
|ClinicalTrials.gov Identifier: NCT00544726|
Recruitment Status : Unknown
Verified October 2007 by Rabin Medical Center.
Recruitment status was: Enrolling by invitation
First Posted : October 16, 2007
Last Update Posted : April 8, 2008
Patients suffering from pulmonary arterial hypertension (PAH) frequently remain symptomatic despite medical therapy. Symptoms include breathlessness, poor exercise capacity and reduced quality of life.
In many other serious heart or lung diseases it has been shown that physical rehabilitation improves patient's fitness and quality of life. In PAH there are no clear guidelines and in general physical activity has traditionally been discouraged, although evidence for this advice is lacking. Interesting research project in Germany showed significant benefit for in-patient rehabilitation in PAH patients.
In this study we will perform a controlled clinical study of out-patient rehabilitation of patients with PAH. We hypothesize that physical training of patients will result in increased exercise capacity and improved quality of life.
|Condition or disease||Intervention/treatment|
|Pulmonary Arterial Hypertension||Behavioral: Physical training Behavioral: No training|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||45 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||February 2008|
Active Comparator: 1
|Behavioral: Physical training|
Placebo Comparator: 2
No physical training
|Behavioral: No training|
- Six minute walking distance [ Time Frame: 3 months ]
- New York Heart Association (NYHA) functional class [ Time Frame: 3 months ]
- Echocardiographic parameters [ Time Frame: 3 months ]
- Quality of life as assessed by the SF-36 [ Time Frame: 3 months ]
- Performance in cardiopulmonary exercise test [ Time Frame: 3 months ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00544726
|Pulmonary Institute, Rabin Medical Center|
|Petach Tikva, Israel, 49100|
|Study Director:||Mordechai R Kramer, MD||Rabin Medical Center|