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The Use of Irvingia Gabonensis (Bush Mango)and Cissus Quadrangularis to Reduce Weight and Blood Lipids

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00526682
First Posted: September 10, 2007
Last Update Posted: September 10, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Gateway Health Alliance
  Purpose
Hypothesis: Cissus quadrangularis as well as Irvingia gabonensis are used in weight management and related conditions. This study set out to investigate if a combination of the two could have additional benefits to overweight and obese people.

Condition Intervention
Obesity Overweight Dyslipidemia Dietary Supplement: Irvingia/cissus combo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: The Effect of Combining Cissus Quadrangularis and Irvingia Gabonensis on Obesity and Obesity Related Diseases

Resource links provided by NLM:


Further study details as provided by Gateway Health Alliance:

Primary Outcome Measures:
  • Weight change [ Time Frame: 10 weeks ]

Secondary Outcome Measures:
  • Blood lipids Body fat Fasting blood glucose [ Time Frame: 10 weeks ]

Enrollment: 72
Study Start Date: January 2007
Study Completion Date: April 2007
Arms Assigned Interventions
Active Comparator: 1
Comparison of actives for synergy
Dietary Supplement: Irvingia/cissus combo
Other Name: Irvingia cissus combo

Detailed Description:

To assess and compare the effects of administration of Cissus quadrangularis (Linn) and a Cissus quadrangularis /Irvingia gabonensis combination on body weight blood pressure, fasting blood glucose, plasma total and LDL cholesterol in 72 overweight and obese subjects.

The study was a 10 week randomized, double-blind, placebo-controlled design, involving 72 obese or overweight participants. Participants were randomly divided into three groups (24 participants/ group):

Group 1 - Placebo; Group 2 - Cissus quadrangularis (CQ); Group 3 - Cissus quadrangularis and Irvingia gabonensis (CQ-IG).

The placebo (250mg) or active formulations ((150 mg CQ and 250 mg CQ-IG) were administered twice daily before meals. Weight as well as fasting blood was taken at baseline, and at 4, 8 and 10 weeks.

No major dietary changes or exercises were suggested during the study.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI>26kg/m2

Exclusion Criteria:

  • Diabetics
  • Pregnant and lactating
  • Subjects on any other weight loss program
  • Following any specific low calorie diet
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00526682


Sponsors and Collaborators
Gateway Health Alliance
Investigators
Principal Investigator: Julius E OBEN, PhD University of Yaounde 1
  More Information

ClinicalTrials.gov Identifier: NCT00526682     History of Changes
Other Study ID Numbers: GHACT010
First Submitted: September 6, 2007
First Posted: September 10, 2007
Last Update Posted: September 10, 2007
Last Verified: September 2007

Keywords provided by Gateway Health Alliance:
Antiobesity
Weight loss

Additional relevant MeSH terms:
Obesity
Overweight
Dyslipidemias
Overnutrition
Nutrition Disorders
Body Weight
Signs and Symptoms
Lipid Metabolism Disorders
Metabolic Diseases