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Preoperative Hepatic Arterial Infusion Chemotherapy

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2007 by IRCCS San Raffaele.
Recruitment status was  Active, not recruiting
Information provided by:
IRCCS San Raffaele Identifier:
First received: August 28, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
To assess the feasibility and results of liver resection after preoperative hepatic artery infusion (HAI) chemotherapy with FUDR.

Condition Intervention
Colorectal Liver Metastases
Drug: Floxuridine FUDR

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective
Official Title: Preoperative Hepatic Arterial Infusion Chemotherapy in Patients Undergoing Liver Resection for Colorectal Liver Metastases

Resource links provided by NLM:

Further study details as provided by IRCCS San Raffaele:

Study Start Date: December 1995
Detailed Description:

Between 1995 and 2004, 239 patients with isolated colorectal liver metastases received HAI chemotherapy with neoadjuvant intent. Fifty of these patients underwent subsequent curative liver resection (HAI group).

Postoperative morbidity, liver function tests, and long term outcomes were evaluated. Adverse events related to HAI chemotherapy were also evaluated.


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Unresectable liver metastases
  • Potentially resectable liver metastases

Exclusion Criteria:

  • Extrahepatic disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00522509

Department of Surgery - Liver Unit, Scientific Institute San Raffaele,
Milan, Italy, 20132
Sponsors and Collaborators
IRCCS San Raffaele
Principal Investigator: Luca Aldrighetti, M.D, PhD Department of Surgery - Liver Unit, Scientific Institute San Raffaele,
  More Information Identifier: NCT00522509     History of Changes
Other Study ID Numbers: Neoadjuvant HAIC 
Study First Received: August 28, 2007
Last Updated: August 28, 2007
Health Authority: Italy: Istituto Superiore di Sanità

Additional relevant MeSH terms:
Neoplasm Metastasis
Liver Neoplasms
Neoplastic Processes
Pathologic Processes
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents processed this record on October 21, 2016