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Role of Volatile Anesthetics for Hepatic Protection

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ClinicalTrials.gov Identifier: NCT00516711
Recruitment Status : Completed
First Posted : August 15, 2007
Last Update Posted : September 15, 2010
Sponsor:
Information provided by:
University of Zurich

Brief Summary:
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Condition or disease Intervention/treatment Phase
Reperfusion Injury Drug: Sevoflurane Not Applicable

Detailed Description:
Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion
Study Start Date : March 2006
Actual Primary Completion Date : December 2007
Actual Study Completion Date : December 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Sevoflurane




Primary Outcome Measures :
  1. Blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT)


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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Older than 18 years of age
  • Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria:

  • Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)
  • Liver cirrhosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00516711


Locations
Switzerland
University Hospital of Zurich
Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Investigators
Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00516711     History of Changes
Other Study ID Numbers: StV 5-2006
First Posted: August 15, 2007    Key Record Dates
Last Update Posted: September 15, 2010
Last Verified: August 2007

Keywords provided by University of Zurich:
Surgery with Pringle maneuver needed for liver resection

Additional relevant MeSH terms:
Reperfusion Injury
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications
Pathologic Processes
Anesthetics
Sevoflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General