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Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

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ClinicalTrials.gov Identifier: NCT00516230
Recruitment Status : Unknown
Verified August 2007 by Samsung Medical Center.
Recruitment status was:  Recruiting
First Posted : August 15, 2007
Last Update Posted : August 15, 2007
Sponsor:
Information provided by:

Study Description
Brief Summary:
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.

Condition or disease
Colonic Neoplasms

Detailed Description:
Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).

Study Design

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
Study Start Date : January 2006
Estimated Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Colorectal cancer

Exclusion Criteria:

  • Histology showing other than adenocarcinoma
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00516230


Contacts
Contact: Dong Kyung Chang, M.D. Ph.D +82-2-3410-3409 dkchang@skku.edu
Contact: Tae Kuen Kim +82-2-3410-2975 tggo.kim@samsung.com

Locations
Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Gangnam-gu, Korea, Republic of, 135-710
Contact: Tae Kyun Kim    +82-2-3410-2975    tggo.kim@samsung.com   
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Dong Kyung Chang, M.D. Ph.D Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
More Information

ClinicalTrials.gov Identifier: NCT00516230     History of Changes
Other Study ID Numbers: SMC-2007-04-080
First Posted: August 15, 2007    Key Record Dates
Last Update Posted: August 15, 2007
Last Verified: August 2007

Keywords provided by Samsung Medical Center:
Colonic Neoplasms
Lynch syndrome

Additional relevant MeSH terms:
Colorectal Neoplasms
Colonic Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases