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Hemodynamic Parameters in Euthyroid Patients With Thyroid Nodules

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00507897
Recruitment Status : Terminated (The received reliability with increase in quantity of participants of research did not vary)
First Posted : July 27, 2007
Last Update Posted : February 7, 2008
Information provided by:
Yaroslavl State Medical Academy

Brief Summary:
The purpose of this study is to determine the relationship of hemodynamic parameters with the level of thyroid hormones and the histological structure of thyroid nodules in euthyroid patients.

Condition or disease
Thyroid Nodules

Detailed Description:

As opposed to widely investigated condition of cardiovascular system in patients with functional disorders of thyroid gland, the relationship between thyroid hormones and hemodynamic parameters in euthyroid patients remains not enough clear.

We detect the parameters of blood pressure and thyroid hormones in euthyroid patients with thyroid nodules directly before planned operation on the thyroid gland.

As the study is carries out directly before operation, that assumes presence of preoperative stress in patients, activity of the sympatho - adrenal system is estimated in addition.

On the one hand, the design of our research will allow to estimate relationship of thyroid hormones with the parameters of blood pressure in conditions of euthyroidism, on the other hand - to investigate features of blood pressure in patients with thyroid nodules.

The research of the patients in the preoperative period will enable to select the group of patients without pathology of cardiovascular system whose increased blood pressure is connected with preoperative stress, that in turn will allow to exclude influence of the pathology of the cardiovascular system on studied correlation.

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Study Type : Observational
Estimated Enrollment : 100 participants
Time Perspective: Prospective
Actual Study Completion Date : December 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Thyroid Diseases

Cohort: Patients with normal blood pressure scheduled to have thyroid nodules surgically removed
Patients from group A not receiving any drugs and who lack other pathology, gender and age matched group B1
Cohort: Patients with increased blood pressure scheduled to have thyroid nodules surgically removed
Patients from group B not receiving any drugs and who lack other pathology, gender and age matched group A1

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Euthyroid patients with thyroid nodules before operation on the thyroid gland

Exclusion Criteria:

  • Hyperthyroidism
  • Hypothyroidism

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00507897

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Russian Federation
Yaroslavl State Medical Academy
Yaroslavl, Russian Federation, 150000
Sponsors and Collaborators
Yaroslavl State Medical Academy
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Study Chair: Yuriy Alexandrov, Professor Yaroslavl State Medical Academy

Layout table for additonal information Identifier: NCT00507897    
Other Study ID Numbers: ESheverdova-1
First Posted: July 27, 2007    Key Record Dates
Last Update Posted: February 7, 2008
Last Verified: February 2008
Keywords provided by Yaroslavl State Medical Academy:
thyroid nodules, blood pressure, thyroid hormones
Additional relevant MeSH terms:
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Thyroid Nodule
Thyroid Diseases
Endocrine System Diseases
Thyroid Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Head and Neck Neoplasms