Almond Dose Response Study.
|ClinicalTrials.gov Identifier: NCT00507520|
Recruitment Status : Completed
First Posted : July 26, 2007
Last Update Posted : July 26, 2007
|Condition or disease||Intervention/treatment||Phase|
|Hyperlipidemia Diet Therapy Cardiovascular Disease||Procedure: Full dose almonds Procedure: Half dose almonds+half dose muffin Procedure: Full dose whole wheat muffin||Phase 2|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||27 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||The Effect of Almonds on Coronary Heart Disease Risk Factors: Dose Response Study.|
|Study Start Date :||December 1999|
|Study Completion Date :||September 2001|
- Lipids: Total Cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoproteins B and AI
- Glycemic control: Glucose, insulin, C-peptide (blood and urine).
- Clotting Factors: fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor, urokinase, factor VII and factor VIII.
- Oxidative Stress: Oxidized LDL-C as conjugated dienes in isolated LDL-C fraction, serum carotenoids, vitamin E, vitamin A; 8-hydroxy-2-deoxyguanosine (8-HDG) in isolated blood lymphocytes; malondialdehyde (MDA); urinary isoprostanes.
- Nitric Oxide: Pulmonary (expired air) NO measured as a marker of whole body NO production and olfactory epithelial NO production in perfused nasal air.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00507520
|St. Michael's Hospital|
|Toronto, Ontario, Canada, M5S 2T2|
|Principal Investigator:||David JA Jenkins, MD, PhD||University of Toronto, St. Michael's Hospital|
|Study Director:||Cyril WC Kendall, PhD||University of Toronto, St. Michael's Hospital|