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Melatonin and Adiponectin in Hypertensive Kidney Transplant

This study has been completed.
Information provided by:
Sheba Medical Center Identifier:
First received: July 8, 2007
Last updated: June 29, 2009
Last verified: June 2009

Recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome. We have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients.

The aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. Secondly, to ask if there is any correlation between melatonin secretion and adiponectin levels.

Hypertension Kidney Transplant

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 60
Study Start Date: September 2007
kidney transplant with hypertension
hypertensive patients with native kidneys
healthy controls


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
group1- patients from the kidney transplant unit, sheba medical center group2- patients from hypertension unit,sheba medical center

Inclusion Criteria:

  • hypertension
  • kidney transplantation ( group 1)
  • good renal function

Exclusion Criteria:

  • diabetes mellitus
  • cancer
  • renal failure
  Contacts and Locations
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Please refer to this study by its identifier: NCT00498576

Sheba Medical Center
Ramat-gan, Israel
Sponsors and Collaborators
Sheba Medical Center
Principal Investigator: Avshalom Leibowitz, MD
  More Information

Responsible Party: leibowitz avshalom, Sheba Medical Center Identifier: NCT00498576     History of Changes
Other Study ID Numbers: SHEBA-07-4730-AL-CTIL
Study First Received: July 8, 2007
Last Updated: June 29, 2009

Keywords provided by Sheba Medical Center:
kidney transplant

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs
Central Nervous System Depressants processed this record on September 21, 2017