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Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-wave Myocardial Infarction by MRI

This study has been completed.
Information provided by (Responsible Party):
Duke University Identifier:
First received: June 26, 2007
Last updated: May 24, 2013
Last verified: June 2007
The first aim of this study is to determine how often unrecognized myocardial infarction occur in patients using a magnetic resonance imaging (MRI) technique (known as delayed enhancement MRI), as compared to the electrocardiogram. The second aim of this study is to determine the severity of coronary heart disease of the patients with unrecognized myocardial infarction. The final aim is to determine how the presence of unrecognized myocardial infarction detected by the MRI affects lifespan.

Coronary Arteriosclerosis Myocardial Infarction

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Unrecognized Non-Q-wave Myocardial Infarction: Prevalence, Angiographic Correlation, and Prognostic Significance in Patients With Suspected Coronary Disease

Resource links provided by NLM:

Further study details as provided by Duke University:

Enrollment: 185
Study Start Date: January 1998
Study Completion Date: November 2006
Detailed Description:
Unrecognized myocardial infarction (MI) is known to constitute a substantial portion of lethal coronary heart disease. However, since the diagnosis of unrecognized MI is based on the appearance of incidental Q-waves on 12-lead electrocardiography, the syndrome of unrecognized non-Q-wave MI has not been described. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can accurately identify non-Q-wave MI. The aims of this study are three-fold: 1. to determine the prevalence of unrecognized non-Q-wave and Q-wave MI, 2. to define predictors of unrecognized non-Q-wave MI, 3. to determine the prognostic significance of unrecognized non-Q-wave MI.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with suspected coronary artery disease referred for invasive coronary angiography

Exclusion Criteria:

  • Clinical history of myocardial infarction
  • Percutaneous coronary intervention
  • Coronary artery bypass surgery
  • Known uncured malignancy
  • History of hypertrophic cardiomyopathy, myocarditis, or infiltrative heart disease
  • Contraindication of magnetic resonance imaging
  Contacts and Locations
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Please refer to this study by its identifier: NCT00493168

United States, Illinois
Northwestern University Medical School
Chicago, Illinois, United States, 60611
United States, North Carolina
Duke Cardiovascular Magnetic Resonance Center
Durham, North Carolina, United States, 27710
Sponsors and Collaborators
Duke University
Principal Investigator: Han W Kim, MD Duke Cardiovascular Magnetic Resonance Center
Principal Investigator: Raymond J Kim, MD Duke Cardiovascular Magnetic Resonance Center
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Duke University Identifier: NCT00493168     History of Changes
Other Study ID Numbers: 3434
Study First Received: June 26, 2007
Last Updated: May 24, 2013

Additional relevant MeSH terms:
Myocardial Infarction
Coronary Artery Disease
Myocardial Ischemia
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases
Coronary Disease processed this record on September 21, 2017