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Insulin Resistance : Heart Failure

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2007 by University of Dundee.
Recruitment status was:  Recruiting
Information provided by:
University of Dundee Identifier:
First received: June 13, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted

Whether insulin resistance common among Chronic Heart Failure (CHF) patients in Tayside and identify factors associated with insulin resistance in CHF.

We also want to identify mechanism for the impaired exercise capacity and reduced peak VO2 in CHF

Congestive Heart Failure Heart Failure

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Insulin Resistance: A New Target in Heart Failure

Resource links provided by NLM:

Further study details as provided by University of Dundee:

Study Start Date: August 2006
  Show Detailed Description


Ages Eligible for Study:   30 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • One hundred patients with Left ventricular Ejection Friction (LVEF) <35% in NYHA class I II III or IV; aged 30-90, attending the CHF clinic will be studied
  • Diagnosis of CHF will be based on medical history of exertional dyspneoa, muscle fatigue and/or fluid retention and diminished LVEF (LVEF<35%)
  • The diagnosis of ischemic heart disease will be based on documentation of previous myocardial infarction, coronary artery bypass surgery or pathologic findings on coronary angiography. Idiopathic dilated cardiomyopathy will be diagnosed in the absence of a specific etiology for left ventricular dysfunction and on the basis of normal coronary arteries
  • All patients should be stable with their treatment and no change in their treatment regimen for > 6 weeks before the study
  • Patients with CHF due to coronary artery disease are more likely to have abnormalities in glucose metabolism than are patients with CHF due to idiopathic dilated cardiomyopathy. Therefore, we also plan to study a control group [n=50] of age and sex and BMI matched patients divided into 2 groups 25 with coronary artery disease without heart failure and 25 healthy control. These patients will be identified from the Cardiology Clinics

Exclusion Criteria:

  • Patients with decompensated CHF with signs of congestion
  • Since the objective of the study is to assess prevalence of insulin resistance in CHF and not CHF secondary to other diseases like diabetes mellitus (DM), patients suffering from DM will be excluded
  • Individual found during study cognitively impaired rendering them incapable to take part
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00486967

Contact: Matlooba A ALZadjali, BSc, MD, MPH 0044(0)1382 660111 ext 33176

United Kingdom
University of Dundee Recruiting
Dundee, United Kingdom, DD1 9SY
Contact: James Houston    0044(0)1382384664   
Sub-Investigator: MATLOOBA A ALZadjali, BSC,MD,MPH         
Sponsors and Collaborators
University of Dundee
Principal Investigator: Chim C Lang, MD, FRCP University of Dundee, Scotland, UK
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00486967     History of Changes
Other Study ID Numbers: MAT001
Study First Received: June 13, 2007
Last Updated: June 13, 2007

Keywords provided by University of Dundee:
Insulin resistance, heart failure, congestive heart failure,
Peak VO2, Endothelial Function, Leptin, TNF.

Additional relevant MeSH terms:
Heart Failure
Insulin Resistance
Heart Diseases
Cardiovascular Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on September 21, 2017