Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease (PC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00478166
Recruitment Status : Completed
First Posted : May 24, 2007
Last Update Posted : October 5, 2015
VA Office of Research and Development
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate. Determining the functionality of this brain region may help us diagnose AD more accurately, thus allowing earlier treatment.

Condition or disease
Magnetic Resonance Imaging Alzheimer's Disease Dementia Adult Children Risk

Detailed Description:
The posterior cingulate is a key brain region suggested by recent studies to be affected in people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the course of AD and the region may have reduced function even prior to the onset of symptoms, further understanding of its functional role and its relationship to other brain regions may be helpful in detecting AD earlier and in monitoring disease progression and treatment. This project examines the role of the PC and its connections to other brain regions using functional magnetic resonance imaging (fMRI), a technique that allows us to examine the brain at work during tests of memory and decision-making. The main goal is to see if functional connections between brain regions are modulated by risk for AD.

Study Type : Observational
Estimated Enrollment : 206 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease
Study Start Date : July 2005
Actual Study Completion Date : October 2007

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Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
People who are enrolled in the Wisconsin Registry for AD Prevention (WRAP), recruited from Memory clinics and the community.

Inclusion Criteria:

  • Cognitively healthy
  • (Controls Only) Parents survived past age 70 and did/do not have memory problems.

Exclusion Criteria:

  • Claustrophobia
  • Metallic or electronic implants

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00478166

United States, Wisconsin
University of Wisconsin - Wisconsin Comprehensive Memory Program
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
VA Office of Research and Development
Principal Investigator: Sterling C Johnson, PhD University of Wisconsin/VA GRECC

Additional Information:
Responsible Party: University of Wisconsin, Madison Identifier: NCT00478166     History of Changes
Other Study ID Numbers: 2004-174
First Posted: May 24, 2007    Key Record Dates
Last Update Posted: October 5, 2015
Last Verified: April 2011

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders