Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms
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ClinicalTrials.gov Identifier: NCT00476372 |
Recruitment Status
:
Completed
First Posted
: May 22, 2007
Last Update Posted
: January 14, 2013
|
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Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the type and severity of cognitive impairment. This discrepancy can in part be caused by the lack of distinction between patients with different motor symptoms and disease severity.
Objective: To identify the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the severity and type of cognitive dysfunction in patients with idiopathic PD categorized according to motor symptoms and disease severity.
Methods: the population of patients with PD in the old county of Aarhus is described on the background of medical records, and stratified in accordance to age, sex and cardinal symptoms. Through proportional allocation a sample of a minimum of 50 patients with PD is drawn from the population. The patients and 30 healthy matched controls will undergo comprehensive neuropsychological assessment including tests of language, memory, executive function, and visuospatial function. Furthermore, all participants will be screened for depression (Geriatric Depression Scale) and psychiatric symptoms (Neuropsychiatric Inventory and Symptom Checklist). The patients will be categorized in accordance with their motor symptoms via cluster analysis for the purpose of analyzing the effect of psychiatric symptoms, depression, and age of disease onset, disease duration, and medication on cognition.
Condition or disease |
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Parkinson's Disease |
Study Type : | Observational |
Actual Enrollment : | 107 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms -the Relation Between Cognitive Deficits and Comorbid Psychiatric Disorders, Medication, and Age at Disease Onset |
Study Start Date : | August 2007 |
Actual Primary Completion Date : | December 2011 |
Actual Study Completion Date : | December 2011 |

Group/Cohort |
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Parkinson's disease
Pt with parkinsons disease
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- cognitive measures [ Time Frame: 1 hour ]

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Ages Eligible for Study: | 50 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Idiopathic Parkinson's in accordance to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria,
- Born and raised in Denmark ,
- >50 years
Exclusion Criteria:
- Cerebrovascular disease,
- Dementia not caused by Parkinson's Disease,
- Metabolism anomaly,
- Abuse of drugs, medication or alcohol,
- History of head injuries,
- Severe psychiatric disorder, excluding depression,
- Resident outside the region of Aarhus h) DBS -

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00476372
Denmark | |
Aarhus Universitetshospital | |
Aarhus, Denmark, 8000 |
Study Chair: | Karen Østergaard, neurologist | Aarhus Universitetshospital | |
Study Chair: | Lars Larsen, MSc, PhD, Associate Professor | The Institute of Psychology |
Responsible Party: | University of Aarhus |
ClinicalTrials.gov Identifier: | NCT00476372 History of Changes |
Other Study ID Numbers: |
UAarhus |
First Posted: | May 22, 2007 Key Record Dates |
Last Update Posted: | January 14, 2013 |
Last Verified: | January 2013 |
Keywords provided by University of Aarhus:
neuropsychology cognitive impairment motor disorder parkinson's disease |
Additional relevant MeSH terms:
Parkinson Disease Cognitive Dysfunction Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases |
Nervous System Diseases Movement Disorders Neurodegenerative Diseases Cognition Disorders Neurocognitive Disorders Mental Disorders |