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Older Adult Training Study With Creatine and CLA (OTR)

This study has been completed.
Information provided by:
McMaster University Identifier:
First received: May 15, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Condition Intervention
Sarcopenia Behavioral: Training Drug: Creatine Monohydrate, Conjugated Linoleic Acid

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Prevention
Official Title: Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

Resource links provided by NLM:

Further study details as provided by McMaster University:

Primary Outcome Measures:
  • a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption) [ Time Frame: six months ]

Secondary Outcome Measures:
  • a. Functional capacity b. Strength with weight machines [ Time Frame: six months ]

Enrollment: 39
Study Start Date: August 2003
Study Completion Date: September 2004
Detailed Description:
Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).

Ages Eligible for Study:   65 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy,
  • Ambulatory,
  • Recreationally active,
  • Community dwelling

Exclusion Criteria:

  • Evidence of coronary heart disease;
  • Congestive heart disease;
  • Uncontrolled hypertension;
  • Chronic obstructive pulmonary disease;
  • Diabetes mellitus;
  • Renal failure;
  • Major orthopedic disability; and
  • Smoking
  Contacts and Locations
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Please refer to this study by its identifier: NCT00473902

Canada, Ontario
McMaster University Medical Center
Hamilton, Ontario, Canada, L8N 3Z5
Sponsors and Collaborators
Hamilton Health Sciences Corporation
Principal Investigator: Mark A Tarnopolsky, M.D., Ph.D. McMaster University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00473902     History of Changes
Other Study ID Numbers: Older Adult Training Study
Study First Received: May 15, 2007
Last Updated: May 15, 2007

Additional relevant MeSH terms:
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Pathological Conditions, Anatomical
Signs and Symptoms processed this record on August 18, 2017