Older Adult Training Study With Creatine and CLA (OTR)

This study has been completed.
Information provided by:
McMaster University
ClinicalTrials.gov Identifier:
First received: May 15, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Condition Intervention
Behavioral: Training
Drug: Creatine Monohydrate, Conjugated Linoleic Acid

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

Resource links provided by NLM:

Further study details as provided by McMaster University:

Primary Outcome Measures:
  • a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption) [ Time Frame: six months ]

Secondary Outcome Measures:
  • a. Functional capacity b. Strength with weight machines [ Time Frame: six months ]

Enrollment: 39
Study Start Date: August 2003
Study Completion Date: September 2004
Detailed Description:
Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).

Ages Eligible for Study:   65 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy,
  • Ambulatory,
  • Recreationally active,
  • Community dwelling

Exclusion Criteria:

  • Evidence of coronary heart disease;
  • Congestive heart disease;
  • Uncontrolled hypertension;
  • Chronic obstructive pulmonary disease;
  • Diabetes mellitus;
  • Renal failure;
  • Major orthopedic disability; and
  • Smoking
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00473902

Canada, Ontario
McMaster University Medical Center
Hamilton, Ontario, Canada, L8N 3Z5
Sponsors and Collaborators
Hamilton Health Sciences Corporation
Principal Investigator: Mark A Tarnopolsky, M.D., Ph.D. McMaster University
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00473902     History of Changes
Other Study ID Numbers: Older Adult Training Study 
Study First Received: May 15, 2007
Last Updated: May 15, 2007
Health Authority: Canada: Health Canada

Additional relevant MeSH terms:
Muscular Atrophy
Nervous System Diseases
Neurologic Manifestations
Neuromuscular Manifestations
Pathological Conditions, Anatomical
Signs and Symptoms

ClinicalTrials.gov processed this record on April 27, 2016