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Immediate Effect of Light on Reproductive Hormones in Women: a Role of the Spectrum

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00467805
Recruitment Status : Completed
First Posted : May 1, 2007
Last Update Posted : April 9, 2010
Information provided by:
Russian Academy of Medical Sciences

Brief Summary:
The study investigates an acute effect of white-appearing LED light (with a peak in blue portion) vs. red LED light of similar irradiance on reproductive hormones in healthy women.

Condition or disease Intervention/treatment Phase
Healthy Procedure: Light therapy Not Applicable

Detailed Description:
Sixteen healthy women came to the laboratory at 7:30 (wearing dark goggles) at two occasions (separated by 2-3 days, first time - at the 3rd-8th day of their menstrual cycle) to be exposed for 45' to white-appearing or red LED light (sequential allocation). The white light has a distinct peak at 460 nm, the narrow-band red light peaked at 651 nm. The LED devices were positioned at the distance of 50 cm (white) and 45 cm (red) from the eyes to be matched by irradiance (approximately 7.0 microWt/m2); background light in direction of gaze was 5-10 lux. Blood and saliva samples were collected before, in the middle, and during the last minutes of the 45' exposure to be measured later for concentration of luteinizing hormone, follicle-stimulating hormone, prolactin, estrogen, progesterone, and also - for cortisol and melatonin (the last one - in saliva) as well-studied indicators of the direct effect of light.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Study Start Date : March 2009
Actual Primary Completion Date : May 2009
Actual Study Completion Date : October 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hormones

Primary Outcome Measures :
  1. Reproductive hormones concentration [ Time Frame: 3 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age 18-45 y
  • normal (21-35 days) menstrual cycle
  • good and stable general health
  • normal body weight index 18.5-29.9
  • normal sleep-wake regimen
  • living close to the laboratory (<7' by walk)
  • "good"cubital veins

Exclusion Criteria:

  • difficulty to contact
  • travel over several time zones during last month
  • medications known to interfere with hormone release

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00467805

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Russian Federation
Institute of Internal Medicine SB RAMS
Novosibirsk, Russian Federation, 630089
Sponsors and Collaborators
Russian Academy of Medical Sciences
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Study Chair: Konstantin V Danilenko, MD Institute of Internal Medicine SB RAMS
Principal Investigator: Oksana Y. Sergeeva, PhD student Institute of Internal Medicine SB RAMS

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Responsible Party: Outside In Identifier: NCT00467805    
Other Study ID Numbers: M-s4c
First Posted: May 1, 2007    Key Record Dates
Last Update Posted: April 9, 2010
Last Verified: October 2009
Keywords provided by Russian Academy of Medical Sciences:
Light exposure
light spectrum
reproductive hormones
Additional relevant MeSH terms:
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Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs