Effect of Heredity and Environment on Asthma Development and Severity in Puerto Rican Children
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Genes, Home Allergens, and Asthma in Puerto Rican Children|
- Effect of certain genes and allergens on the development and severity of asthma in Puerto Rican children [ Time Frame: Measured at participants' two study visits ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||August 2006|
|Study Completion Date:||June 2010|
|Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
Asthma is a chronic disease that causes constriction of the airways. People with asthma may experience wheezing, coughing, chest tightness, and trouble breathing. Although asthma is a major public health problem among Puerto Ricans, little research has been done to determine the influence of heredity and environment on the disease in this population. To learn more about these relationships, this study will examine the effects of certain genes and allergens on the development and severity of asthma in Puerto Rican children.
This observational study will recruit both children with asthma and children without asthma. Participants will meet with study staff twice during the study. The first visit will take place at participants' homes. Participants will complete questionnaires about demographics, respiratory and general health, and household characteristics. Lung function testing, collection of blood samples, and collection of household dust samples will also take place at the home-based visit. The second visit will take place at the study site. At this visit, participants will undergo allergy tests on the skin and a methacholine challenge test to assess their airway responsiveness and asthma severity. The methacholine challenge test will involve inhaling mist through a mouthpiece and blowing forcefully into a special apparatus called a spirometer. Parents will be asked to provide information about their children's exposure to pets in early life. Each visit will last approximately 1.5 hours and will be scheduled close to the date on which a participant enters the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00461227
|University of Puerto Rico|
|San Juan, Puerto Rico|
|Principal Investigator:||Juan C. Celedon, MD, DrPH||Brigham and Women's Hospital|