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Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children (ALTAC)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2007 by Liverpool School of Tropical Medicine.
Recruitment status was:  Not yet recruiting
Thrasher Research Fund
Information provided by:
Liverpool School of Tropical Medicine Identifier:
First received: April 4, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted
Study based in Southern Ethiopia Purpose - to explore if children in contact with adults with TB have positive acute reactants such as IFN-y and other cytokine responses; if these responses discriminate between high and low risk of disease progression and whether these could be incorporated into improved diagnostic approaches.


Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children

Resource links provided by NLM:

Further study details as provided by Liverpool School of Tropical Medicine:

Estimated Enrollment: 500
Study Start Date: May 2007
Estimated Study Completion Date: October 2009
Detailed Description:

The study follows children in contact with TB. Those with positive TST will be offered chemoprophylaxis and all children will be followed for 2 years to describe IFN-y responses over time, identify symptoms of active TB and if these symptoms are associated with IFN-y and other cytokine responses.

Children with suspicion of TB attending health centres will also be investigated using routine diagnostic tests and IFN-y and other cytokines responses to evaluate if the latter could be used in improved diagnostic approaches.


Ages Eligible for Study:   1 Year to 14 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

- Children - 1 to 14 years old in contact with adults with smear positive TB


- Children with suspicion of TB admitted to the hospital for investigations

Exclusion Criteria:

- Residency > 10 Km from recruitment center


- Patient severely to undergo diagnostic procedures.

  Contacts and Locations
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Please refer to this study by its identifier: NCT00456469

Contact: Luis Cuevas, MD MTropMed 0151 705 3219

Bushullo Major Health Centre Not yet recruiting
Awassa, Southern Region, Ethiopia, 12
Contact: Mohammed Yassin, Dr         
Sub-Investigator: Mohammed Yassin, Dr         
Sponsors and Collaborators
Liverpool School of Tropical Medicine
Thrasher Research Fund
Principal Investigator: Luis Cuevas, Dr Liverpool School of Tropical Medicine