Positive Choice: Prevention for Positive Health
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|ClinicalTrials.gov Identifier: NCT00447707|
Recruitment Status : Completed
First Posted : March 15, 2007
Last Update Posted : January 12, 2017
|Condition or disease||Intervention/treatment||Phase|
|HIV Infections Sexual Risk Behavior Substance Use Risks||Behavioral: Positive Choice||Not Applicable|
A preliminary analysis of baseline data was conducted in January 2006, which indicated that the Positive Choice intervention achieved significant reductions in drug use. These findings were reported in a poster presentation at the XVI International AIDS Conference in Toronto, Canada, in August 2006. A final analysis of outcomes data was conducted in fall 2006 (September - December). Aggregate results from all five study sites are summarized below.
We found a high prevalence of risky behaviors in our sample (497/918, or 54%) and achieved high retention for follow-up in both groups (>80%). We found significant elimination of any drug use in the intervention group at both follow-ups. Among all participants who reported drug use at baseline, 66% of intervention participants continued their drug use at 3-month follow-up compared to 85% of control participants (OR 0.356, p<0.01). At 6-month follow-up, 59% of intervention participants continued their drug use compared to 88% of the control group (<0.001). Among participants who reported methamphetamine use at baseline, 58% continued their methamphetamine use at 3-month follow-up compared to 83% of control participants (OR 0.285, p=0.02). At 6-month follow-up, 53% of intervention participants continued their methamphetamine use compared to 73% of the control group (OR 0.344, p=0.03). We also found significantly less unprotected sex with casual partners by intervention participants at 3-month follow up (69% vs. 87%, OR 0.313, p=0.04), and fewer intervention participants who exceeded the recommended number of drinks per week at 3-months (53% vs. 78%, OR 0.310, p=0.02) Our findings indicate that the Positive Choice program was effective at reducing important behavioral risks among HIV-positive adults in care. Positive Choice is an appropriate and effective adjunct to routine medical care for HIV-positive adults.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||497 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Positive Choice: Prevention for Positive Health|
|Study Start Date :||December 2003|
|Study Completion Date :||September 2006|
- Elimination of risky drinking, illicit alcohol use, unprotected sex, and non-disclosure of HIV status to sex partners.
- Measures of change in risky alcohol use, illicit drug use, unprotected sex, and non-disclosure of HIV status to sex partners.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00447707
|United States, California|
|Adult Immunology Clinic, Highland Hospital|
|Oakland, California, United States, 94602|
|AIDS Project East Bay (APEB)|
|Oakland, California, United States, 94607|
|East Bay AIDS Center (EBAC), Alta Bates Hospital|
|Oakland, California, United States, 94609|
|Kaiser Permanente Medical Center|
|San Francisco, California, United States, 94115|
|Adult Immunology Clinic, Fairmont Hospital|
|San Leandro, California, United States, 94578|
|Principal Investigator:||Barbara Gerbert, PhD||University of California, San Francisco|