Positive Choice: Prevention for Positive Health
Sexual Risk Behavior
Substance Use Risks
Behavioral: Positive Choice
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Educational/Counseling/Training
|Official Title:||Positive Choice: Prevention for Positive Health|
- Elimination of risky drinking, illicit alcohol use, unprotected sex, and non-disclosure of HIV status to sex partners.
- Measures of change in risky alcohol use, illicit drug use, unprotected sex, and non-disclosure of HIV status to sex partners.
|Study Start Date:||December 2003|
|Estimated Study Completion Date:||September 2006|
A preliminary analysis of baseline data was conducted in January 2006, which indicated that the Positive Choice intervention achieved significant reductions in drug use. These findings were reported in a poster presentation at the XVI International AIDS Conference in Toronto, Canada, in August 2006. A final analysis of outcomes data was conducted in fall 2006 (September – December). Aggregate results from all five study sites are summarized below.
We found a high prevalence of risky behaviors in our sample (497/918, or 54%) and achieved high retention for follow-up in both groups (>80%). We found significant elimination of any drug use in the intervention group at both follow-ups. Among all participants who reported drug use at baseline, 66% of intervention participants continued their drug use at 3-month follow-up compared to 85% of control participants (OR 0.356, p<0.01). At 6-month follow-up, 59% of intervention participants continued their drug use compared to 88% of the control group (<0.001). Among participants who reported methamphetamine use at baseline, 58% continued their methamphetamine use at 3-month follow-up compared to 83% of control participants (OR 0.285, p=0.02). At 6-month follow-up, 53% of intervention participants continued their methamphetamine use compared to 73% of the control group (OR 0.344, p=0.03). We also found significantly less unprotected sex with casual partners by intervention participants at 3-month follow up (69% vs. 87%, OR 0.313, p=0.04), and fewer intervention participants who exceeded the recommended number of drinks per week at 3-months (53% vs. 78%, OR 0.310, p=0.02) Our findings indicate that the Positive Choice program was effective at reducing important behavioral risks among HIV-positive adults in care. Positive Choice is an appropriate and effective adjunct to routine medical care for HIV-positive adults.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00447707
|United States, California|
|Adult Immunology Clinic, Highland Hospital|
|Oakland, California, United States, 94602|
|AIDS Project East Bay (APEB)|
|Oakland, California, United States, 94607|
|East Bay AIDS Center (EBAC), Alta Bates Hospital|
|Oakland, California, United States, 94609|
|Kaiser Permanente Medical Center|
|San Francisco, California, United States, 94115|
|Adult Immunology Clinic, Fairmont Hospital|
|San Leandro, California, United States, 94578|
|Principal Investigator:||Barbara Gerbert, PhD||University of California, San Francisco|