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Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

This study has been completed.
Information provided by (Responsible Party):
Melbourne Health Identifier:
First received: March 8, 2007
Last updated: May 28, 2013
Last verified: May 2013
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Condition Intervention Phase
Anaesthesia Drug: Propofol Drug: desflurane Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Resource links provided by NLM:

Further study details as provided by Melbourne Health:

Primary Outcome Measures:
  • Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire [ Time Frame: recovery room stay ]

Enrollment: 300
Study Start Date: August 2006
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Propofol based anaesthetic maintenance with propofol effect-site steered target-controlled infusion, in addition to fentanyl and non-opioid analgesics
Drug: Propofol
target controlled infusion of propofol
Active Comparator: 2
Desflurane based anaesthetic maintenance with manually controlled administration in 100% oxygen in addition to fentanyl and non-opioid analgesics
Drug: desflurane
Anaesthetic maintenance with desflurane

Detailed Description:
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male and female patients
  • Age between 18 and 50 years
  • Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

  • Inadequate English language comprehension
  • Major drug abuse problem
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00446212

Australia, Victoria
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Australia, Western Australia
Royal Perth Hospital
Perth, Western Australia, Australia, 6000
King Edward Memorial Hospital for Women
Subiaco, Western Australia, Australia, 6008
New Zealand
Waikato Hospital
Hamilton, New Zealand
Sponsors and Collaborators
Melbourne Health
Principal Investigator: Kate Leslie, MD Melbourne Health
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Melbourne Health Identifier: NCT00446212     History of Changes
Other Study ID Numbers: 2006.125
Study First Received: March 8, 2007
Last Updated: May 28, 2013

Keywords provided by Melbourne Health:

Additional relevant MeSH terms:
Central Nervous System Depressants
Physiological Effects of Drugs
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Anesthetics, Inhalation processed this record on September 21, 2017