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Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

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ClinicalTrials.gov Identifier: NCT00442091
Recruitment Status : Completed
First Posted : March 1, 2007
Last Update Posted : March 4, 2020
Sponsor:
Information provided by (Responsible Party):
Evy Paulsen, Odense University Hospital

Study Description
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Brief Summary:
Dandelion juice has been used in herbal medicine for at least 1000 years. Vesicular hand eczema is a rare, but difficult to treat, type of hand eczema. One case report has shown that ingestion of dandelion juice could induce a beneficial effect on this type of eczema. The purpose of this study is to test whether this effect can be retrieved in other patients.

Condition or disease Intervention/treatment Phase
Vesicular Palmoplantar Eczema Pompholyx Drug: dandelion juice Not Applicable

Detailed Description:

Dandelion juice has been used in herbal medicine for at least 1000 years. One case report has shown a beneficial effect of this herbal remedy on dyshidrotic hand eczema, and the purpose of this pilot study is to test whether this effect can be retrieved in other patients.

The patients are recruited from our out-patient clinic. Only patients with negative patch tests to Compositae are offered treatment with dandelion juice for 20-30 days.

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 4 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema
Study Start Date : December 2010
Actual Primary Completion Date : December 2019
Actual Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Eczema

Arms and Interventions
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Arm Intervention/treatment
10 ml of dandelion juice twice daily Drug: dandelion juice
10 ml bid for 20-30 days


Outcome Measures
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Primary Outcome Measures :
  1. Improvement in dyshidrotic hand eczema in the study period assessed by HECSI score. [ Time Frame: 3-4 weeks ]

Secondary Outcome Measures :
  1. Improvement in dyshidrotic eczema in the study period assessed by the patient (Visual Analog Scale). [ Time Frame: 3-4 weeks ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adult patients with dyshidrotic eczema for at least 1 year and negative patch test reactions to Compositae (tested within the last 3 years) and normal renal and hepatic blood tests.

Exclusion Criteria:

  • Treatment with systemic steroids or other immunosuppressive/-modulating drugs, including UV therapy, within the last 3 months.
  • Pregnancy, lactation.
  • Compositae contact allergy.
  • Liver or gall bladder disease.
  • Abnormal renal or hepatic blood tests.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00442091


Locations
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Denmark
Department of Dermatology, Odense University Hospital
Odense, Denmark, DK-5000
Sponsors and Collaborators
Odense University Hospital
Investigators
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Principal Investigator: Evy Paulsen, Dr. Department of Dermatology, Odense University Hospital, DK-5000 Odense C
More Information
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Responsible Party: Evy Paulsen, Consultant dermatologist, Ph.D., Odense University Hospital
ClinicalTrials.gov Identifier: NCT00442091    
Other Study ID Numbers: 20070010
First Posted: March 1, 2007    Key Record Dates
Last Update Posted: March 4, 2020
Last Verified: March 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Evy Paulsen, Odense University Hospital:
Dandelion
herbal remedy
hand eczema
Compositae
Additional relevant MeSH terms:
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Eczema
Eczema, Dyshidrotic
Dermatitis
 Skin Diseases
Skin Diseases, Eczematous
Skin Diseases, Vesiculobullous