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Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2009 by Radboud University.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00441753
First Posted: March 1, 2007
Last Update Posted: February 6, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Radboud University
  Purpose
Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.

Condition
Cardiac Arrest Post-Anoxic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Resource links provided by NLM:


Further study details as provided by Radboud University:

Estimated Enrollment: 10
Study Start Date: September 2006
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 95 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients after cardiac arrest, comatose and treated with therapeutic hypothermia
Criteria

Inclusion Criteria:

  • adult patients
  • GCS after return of circulation < 7
  • Induced mild hypothermia for 24 hours
  • primary rhythm ventricular fibrillation

Exclusion Criteria:

  • Thrombolysis
  • Cardiogenic shock with expected survival < 24 hrs
  • Pregnancy
  • No informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00441753


Contacts
Contact: Cornelia Hoedemaekers, MD PhD 00.31.24.3617273 C.Hoedemaekers@ic.umcn.nl

Locations
Netherlands
Radboud University Nijmegen Medical Centre Recruiting
Nijmegen, Netherlands, 6500 HB
Contact: Cornelia Hoedemaekers, MD PhD    00.31.24.3617273    C.Hoedemaekers@ic.umcn.nl   
Sub-Investigator: Koen Simons, MD         
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Cornelia Hoedemaekers, MD PhD Radboud University
Study Director: Johannes van der Hoeven, MD PhD Radboud University
  More Information

Responsible Party: Radboud UNiversity Nijmegen Medical Centre
ClinicalTrials.gov Identifier: NCT00441753     History of Changes
Other Study ID Numbers: KSCH0601
First Submitted: February 28, 2007
First Posted: March 1, 2007
Last Update Posted: February 6, 2009
Last Verified: February 2009

Additional relevant MeSH terms:
Heart Arrest
Hypothermia
Brain Diseases
Hypoxia, Brain
Heart Diseases
Cardiovascular Diseases
Body Temperature Changes
Signs and Symptoms
Central Nervous System Diseases
Nervous System Diseases