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Vasoactive Hormones and Oxygen Saturation During Apneic Events in Patients With Obstructive Sleep Apnea

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ClinicalTrials.gov Identifier: NCT00438412
Recruitment Status : Suspended (It was not possible to recruit enough patients with obstructive sleep apnea.)
First Posted : February 22, 2007
Last Update Posted : April 22, 2008
Sponsor:
Information provided by:
Regional Hospital Holstebro

Brief Summary:

The mechanisms involved in development and maintenance of hypertension in obstructive sleep apnea are not clarified.

We hypothesize that patients with obstructive sleep apnea have an abnormal level of some vasoactive hormones during apneic events during sleep.


Condition or disease
Obstructive Sleep Apnea

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : October 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sleep Apnea
U.S. FDA Resources





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Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Adults, males and females,age 30 -65
Criteria

Patients with Obstructive sleep apnea

Inclusion Criteria:

  • Severe obstructive sleep apnea (apnea-hypopnea index > 30)

Exclusion Criteria:

  • Drug or alcohol abuse
  • Pregnancy
  • History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
  • Diabetes

Healthy Controls

Inclusion Criteria:

  • Apnea-hypopnea index < 10

Exclusion criteria:

  • Drug or alcohol abuse
  • Pregnancy
  • History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
  • Diabetes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00438412


Locations
Denmark
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500
Sponsors and Collaborators
Regional Hospital Holstebro
Investigators
Study Chair: Erling B Pedersen, Professor Regional Hospital Holstebro

Responsible Party: Pia Holland Gjørup, Department of Medical Research
ClinicalTrials.gov Identifier: NCT00438412     History of Changes
Other Study ID Numbers: MED.RES.HOS.2006.01.PHH
First Posted: February 22, 2007    Key Record Dates
Last Update Posted: April 22, 2008
Last Verified: April 2008

Keywords provided by Regional Hospital Holstebro:
Noradrenalin
Endothelin-1
Angiotensin II
Arginine vasopressin
Aldosterone
Renin
Atrial natriuretic peptide
Brain natriuretic peptide
Blood pressure
Apnea

Additional relevant MeSH terms:
Apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases