Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Evaluating How the Nervous System Coordinates Voluntary Movement in the Arm

This study is enrolling participants by invitation only.
Information provided by (Responsible Party):
Paul J. Cordo, Oregon Health and Science University Identifier:
First received: February 19, 2007
Last updated: May 8, 2013
Last verified: May 2013

The purpose of this study is to investigate how the nervous system interprets joint position and movement. This will contribute to a broader knowledge of understanding how the human central nervous system (CNS), which includes the brain and spinal cord, coordinates voluntary movement.

Condition Intervention
Device: Manipulandum table
Device: Tendon vibrator

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Spatial and Temporal Control of Targeted Limb Movements

Further study details as provided by Oregon Health and Science University:

Primary Outcome Measures:
  • Afferent nerve-firing patterns [ Time Frame: At the time of the experimental session ] [ Designated as safety issue: No ]
    Nerve firing patterns are described as the sequence of time intervals between action potentials recorded from the nerve.

  • Task performance levels [ Time Frame: At the time of the experimental session ] [ Designated as safety issue: No ]
    Task performance most often refers to the accuracy and/or precision of limb movement or of the accuracy and/or precision of detection of a somatosensory stimulus.

Estimated Enrollment: 196
Study Start Date: January 1983
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: Manipulandum table
    A table (device) with rotational actuators for the elbow, wrist and fingers. During experimentation, these joints may be moved, or they may be held in a fixed position while the subject exerts volitional torque on the device, or they may be released for the subject to make free movements.
    Device: Tendon vibrator
    A motor that produces mechanical impulses to be transmitted either directly to the muscle belly or indirectly to the muscle's tendon. These impulses stimulate proprioceptive receptors in the muscle.
Detailed Description:

In motor nervous system disorders, such as stroke, the CNS is unable to coordinate normal voluntary movement. This is often caused by malfunctioning proprioception. Proprioception is one's sense of the relative position of neighboring body parts. It allows an individual to feel the orientation of one body part to another. It also provides information about the rate and direction of movement so that an individual can change muscle contraction immediately as incoming information about external forces is received. The two main components of proprioception include sensory nerve cells located in the inner ear and stretch receptors located in muscles, skin, tendons, and joint-supporting ligaments. The purpose of this study is to determine how proprioception is communicated from the stretch receptors in skin, joints, and muscles to the CNS. Specifically, the study will compare the differing roles of agonists, muscles that cause movement, versus antagonists, muscles that oppose agonists, in proprioception.

Participants will be assigned to one of seven substudy groups. Each group will partake in one or more study experiments, which will each take 1 to 4 hours. Participants enrolled in more than one experiment will report to the study site on separate days. For each experiment, the participant will sit at a table with a specialized device, called a manipulandum, which has motorized elbow, wrist, and finger manipulators to control the movement and position of a participant's arm. Depending on the experiment, several forms of joint rotation and arm movement will be carried out by either the participant or the manipulandum. Electrical activity of certain muscles and nerves will be recorded in all experiments by various kinds of electrodes. A tendon vibrator will be used in some experiments to activate muscle receptors that signal to what extent and how fast a muscle is contracting or stretching. Regional anesthesia will also be used in some experiments to reduce sensory input from the skin and joints. Participants will receive follow-up phone calls after an experiment to check for any side effects from procedures.


Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Able bodied adult humans with no ongoing impairments in motor or sensory function.


Exclusion Criteria for Anesthesia:

  • Known neuromuscular abnormalities
  • Known allergies or hypersensitivity to anesthetics
  • Blood clotting or bleeding disorder
  • Use of anticoagulants
  • Psychologically inappropriate behavior (e.g., apprehension, uncertainty with procedure)
  • Significant history of any cardiovascular problem

Exclusion Criteria for Nerve Recording by Electrode:

  • Significant history of fainting or problems with blood pressure control
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00437515

United States, Oregon
Oregon Health and Science University
Portland, Oregon, United States, 97239-3098
Sponsors and Collaborators
Oregon Health and Science University
Principal Investigator: Paul Cordo, PhD Oregon Health and Science University
  More Information

No publications provided

Responsible Party: Paul J. Cordo, Principal Investigator, Oregon Health and Science University Identifier: NCT00437515     History of Changes
Other Study ID Numbers: R01 AR031017, R01AR031017, 5R01AR031017-20
Study First Received: February 19, 2007
Last Updated: May 8, 2013
Health Authority: United States: Federal Government

Keywords provided by Oregon Health and Science University:
central nervous system
agonist muscle
antagonist muscle
muscle spindle
cerebrovascular accident processed this record on February 25, 2015