Acupuncture for Prevention of Radiation-Induced Xerostomia
The goal of this clinical research study is to learn if acupuncture is effective in preventing xerostomia (dry mouth) in cancer patients who receive radiation treatment to the head and neck area. Researchers also want to learn whether acupuncture lowers the severity of dry mouth that is experienced by these patients.
-Investigate if acupuncture is effective in preventing xerostomia among cancer patients at Fudan University Cancer Hospital (Cancer Hospital) who receive radiation treatment to the head and neck area.
- Determine whether acupuncture reduces the severity of xerostomia.
- Determine the feasibility of providing acupuncture treatment to patients at Cancer Hospital who are receiving radiation treatment for cancer of the head and/or neck area.
Other: Standard Care
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Supportive Care
|Official Title:||Acupuncture for Prevention of Radiation-Induced Xerostomia|
- Number of Patients with Xerostomia [ Time Frame: Baseline + 8 additional points in time (baseline, weeks1-7, week 11). ] [ Designated as safety issue: No ]Severity of the xerostomia in both groups compared by testing for group differences in xerostomia scores between baseline and week 7 using a two-sample (unpaired) t test. Repeated measures analyses used in order to detect overall differences in severity over time, differences between groups and the interaction between time and group.
|Study Start Date:||January 2007|
|Estimated Primary Completion Date:||January 2017 (Final data collection date for primary outcome measure)|
Acupuncture Before the Radiation Treatment
Acupuncture for 20 minutes before the radiation therapy session, 3 days a week for 7 weeks.
Experimental: Standard Care
Standard Care Without Acupuncture
Other: Standard Care
Some research suggests that acupuncture may be helpful in stimulating saliva flow in patients with dry mouth caused by radiation treatment. Acupuncture uses very thin needles inserted at certain points on the body that are believed to affect bodily functions.
Before you can start treatment on this study, you will have "screening tests." These tests will help the doctor decide if you are eligible to take part in this study. Your complete medical history will be recorded, and you will have a physical exam. You will also be asked to complete 3 short questionnaires about your quality-of-life and current saliva flow. These should take about 5 minutes to complete. You will be asked to collect saliva in a vial (small tube or jar) for 5 minutes, by allowing saliva to collect in your mouth and then spitting it into the vial. You will be asked to collect saliva twice at each time point. One collection will be like it is described above. The second collection will be after you have held a sour liquid in your mouth for 1 minute. A traditional Chinese medicine diagnosis will also be conducted. This will include diagnosis by a doctor as well as by using a heart-rate machine and taking a photograph of your tongue. This will allow a more objective check of your heart rate and tongue condition.
If you are found to be eligible to take part in the study, you will be randomly assigned (as in the toss of a coin) into 1 of 2 groups. One group will receive acupuncture during their radiation treatment period, and the other will receive standard care without acupuncture. Participants assigned to the acupuncture group will receive acupuncture for 20 minutes before their radiation therapy session, 3 days a week for 7 weeks. Participants in the standard care group will not receive acupuncture.
If you are in the acupuncture group, you will be asked to come to the acupuncture clinic for the treatment, before your radiation treatment. The acupuncturist will put in the needles in certain points of your body (including the chin, wrist, leg, and ear), while you are seated in a chair. The needles will remain in for about 20 minutes.
If you choose to receive medications for dry mouth at any point while on study, your participation on this study will end.
No matter which group you are assigned to, for each of the 7 weeks you are receiving radiation treatment, your vital signs (your blood pressure and pulse) will be checked, and you will be asked about any medications you are taking. You will also complete questionnaires about your quality-of-life and symptoms. Each questionnaire should take about 5 minutes to complete. A saliva sample will also be collected on Weeks 1, 3, 4, 6, and 7. If you are assigned to the acupuncture group, the saliva sample will be collected after the acupuncture treatment on Weeks 1, 4, and 7 and before the treatment on Weeks 3 and 6. A traditional Chinese medicine diagnosis will also be conducted in the middle of radiation treatment, at the end of treatment, and 1 month later. This will include diagnosis by a physician as well as by using a pulse machine and taking a photograph of your tongue.
One month after the end of radiation treatment (Week 11), your vital signs will be checked, you will be asked about any medications you are taking， you will complete the quality of life and symptom questionnaires, and you will provide another saliva sample. After Week 11, your participation on this study is over.
This is an investigational study. Up to 100 patients will take part in this study. All will be enrolled at the Fudan University Cancer Hospital.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00430378
|Fudan University Cancer Hospital|
|Principal Investigator:||Joseph S. Chiang, MD||M.D. Anderson Cancer Center|