Ceftriaxone Vs Levofloxacin on Cytokine Expression in Pneumococcal Pneumonia
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:||Comparison Between Ceftriaxone and Levofloxacin on Cytokine Expression Over Time in Severe Pneumococcal Pneumonia|
- Circulating levels of pro and anti-inflammatory cytokines at 0h, 24, 72 h and 120 h from inclusion
- the relationship between cytokine expression, clinical variables and severity of disease.
|Study Start Date:||August 2004|
|Estimated Study Completion Date:||September 2005|
Bacterial alveolar invasion is followed by a compartmentalized inflammatory response. Data suggest that some antimicrobials may induce a differential release of cytokines, with the potential of either accelerating or down regulating cytokine production.
The aim of our study was to compare the effects of ceftriaxone compared with levofloxacin on cytokine systemic concentrations in patients with pneumococcal pneumonia.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00429975
|Hospital Mutua de Terrassa|
|Terrassa, Barcelona, Spain, 08221|
|Principal Investigator:||ESTHER CALBO, MD||Hospital Mutua de Terrassa|
|Principal Investigator:||MONTSERRAT ALSINA, MD||HOSPITAL MUTUA TERRASSA|
|Principal Investigator:||MARIONA XERCAVINS, MD||Hospital Mutua de Terrassa|
|Principal Investigator:||EVA CUCHI, MD||Hospital Mutua de Terrassa|
|Principal Investigator:||MONICA RODRIGUEZ-CARBALLEIRA, PhD||Hospital Mutua de Terrassa|
|Study Director:||JAVIER GARAU, PhD||Hospital Mutua de Terrassa|