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Long-Term IOP Fluctuation and VF Progression After Triple Procedure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00428740
First Posted: January 30, 2007
Last Update Posted: January 30, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Yonsei University
  Purpose
Long-term intraocular pressure (IOP) fluctuation may be significantly associated with the progression of glaucomatous visual field loss, even in patients kept always low IOP after triple procedure, an effective approach for patients with coexisting glaucoma and visually significant cataracts.

Condition
Glaucoma Filtering Surgery Intraocular Pressure

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Retrospective
Official Title: Long-Term Intraocular Pressure Fluctuation and Visual Field Progression in Glaucoma Patients With Low Intraocular Pressure After Triple Procedure

Resource links provided by NLM:


Further study details as provided by Yonsei University:

Estimated Enrollment: 300
Study Start Date: October 2005
Estimated Study Completion Date: December 2005
Detailed Description:
Previous studies reported that lowering intraocular pressure (IOP) slowed the advancement of visual field damage in glaucoma patients. However, even if the IOP can been substantially lowered, reduction of mean and peak IOP does not always prevent visual field progression.We believe that the long-term IOP fluctuation may play a significant role in visual field deterioration in those patients.
  Eligibility

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Underwent triple procedure
  2. At leas 3 years of follow-up after surgery
  3. IOP <18mmHg at each postoperative visit
  4. A minimum of 5 visual field examinations
  5. A reference visual field defect score of 16 or less
  6. Good reliability indices of visual field

Exclusion Criteria:

  1. Any other significant ocular diseases or intraocular surgical histories,
  2. Diseases that may affect visual field or diabetes
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00428740


Locations
Korea, Republic of
Yonsei University College of Medicine
Seoul, Korea, Republic of, 135-720
Sponsors and Collaborators
Yonsei University
Investigators
Principal Investigator: Gong Je Seong, MD, PhD Yondgong Severance Hospital, Yonsei University College of Medicine
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00428740     History of Changes
Other Study ID Numbers: 3-2006-0388
First Submitted: January 29, 2007
First Posted: January 30, 2007
Last Update Posted: January 30, 2007
Last Verified: January 2007

Additional relevant MeSH terms:
Glaucoma
Ocular Hypertension
Eye Diseases