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Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00422474
Recruitment Status : Unknown
Verified July 2008 by Far Eastern Memorial Hospital.
Recruitment status was:  Recruiting
First Posted : January 17, 2007
Last Update Posted : July 10, 2008
Information provided by:
Far Eastern Memorial Hospital

Brief Summary:

After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke.

The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.

Condition or disease
Cerebrovascular Accident Baroreflexes Autonomic Nervous System Diseases

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Study Type : Observational
Estimated Enrollment : 100 participants
Time Perspective: Prospective
Official Title: Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis
Study Start Date : January 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke
  • 50-80 years old
  • Must have either brain CT or brain MRI done

Exclusion Criteria:

  • NIHSS score > 10
  • Patient could not cooperate
  • Unstable vital sign
  • Atrial fibrillation
  • Transient ischemic attack patient
  • Diabetic patient
  • Impaired renal function (Cr > 2.26 mg/dl)
  • Unstable angina, acute myocardiac infarction, cardiomyopathy patients
  • Patient who has known autonomic dysfunction

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00422474

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Contact: Siupak Lee, M.D.

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Far Eastern Memorial Hospital Recruiting
Panchiao City, Taipei County, Taiwan, 220
Contact: Siupak Lee, M.D.   
Principal Investigator: Siupak Lee, M.D.         
Sub-Investigator: Lung Chan, M.D.         
Sub-Investigator: Dong-feng Yeih, M.D.         
Sponsors and Collaborators
Far Eastern Memorial Hospital
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Principal Investigator: Siupak Lee, M.D. Far Eastern Memorial Hospital
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Responsible Party: Dr. Siupak Lee, Far Eastern Memorial Hospital Identifier: NCT00422474    
Other Study ID Numbers: FEMH-95-C-012
First Posted: January 17, 2007    Key Record Dates
Last Update Posted: July 10, 2008
Last Verified: July 2008
Keywords provided by Far Eastern Memorial Hospital:
Ischemic stroke
Baroreflex sensitivity
Cardiovascular autonomic regulation
Additional relevant MeSH terms:
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Nervous System Diseases
Autonomic Nervous System Diseases
Primary Dysautonomias
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Immune System Diseases