A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function
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Safety and tolerability in patients with hepatic impairment will be assessed by adverse events (AEs), serious adverse events (SAEs) and out of range lab values [ Time Frame: at completion of the study ]
To evaluate the preliminary anti-tumor activity which will be assessed by radiological scans every 6 weeks [ Time Frame: at completion of the study ]
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Completion of the core study is required for participation in the extension.
18 years of age or older
World Health Organization (WHO) Performance Status score of: 0 - you are fully active and more or less as you were before your illness; 1 - you cannot carry out heavy physical work, but can do anything else; or 2 - you are up and about more than half the day, you can look after yourself, but are not well enough to work.
Life expectancy of 3 months or more
Patients with measurable or evaluable disease who have histologically documented advanced solid tumor and who have progressed after systemic therapy or for whom standard systemic therapy does not exist
Severe and/or uncontrolled medical disease
Known diagnosis of human immunodeficiency virus (HIV) infection
Presence of any other active or suspected acute or chronic uncontrolled infection
Severe cardiac insufficiency, with uncontrolled and/or unstable cardiac or coronary artery disease
History of another malignancy within 5 years prior to study entry, except for curatively treated non-melanotic skin cancer or cervical cancer in situ
Other protocol-defined inclusion/exclusion criteria may apply.