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Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2007 by Taichung Veterans General Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00417950
First Posted: January 4, 2007
Last Update Posted: January 4, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Tri-Service General Hospital
Information provided by:
Taichung Veterans General Hospital
  Purpose
To understand if acarbose, an alpha-glucosidase inhibitor usually for treating diabetes, will further lower post meal glucose and inflammatory state when taking together with moderate amount of alcohol during meal tolerance test in subjects with impaired glucose tolerance or mild diabetes.

Condition Intervention
Diabetes Mellitus Impaired Glucose Tolerance Drug: Acarbose

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Taichung Veterans General Hospital:

Primary Outcome Measures:
  • Postprandial hyperglycemia

Secondary Outcome Measures:
  • Postprandial inflammatory responses
  • Postprandial oxidative stress

Estimated Enrollment: 30
Study Start Date: January 2007
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subjects with mild diabetes without prior medications or impaired glucose tolerance

Exclusion Criteria:

  • Pregnancy
  • Recent major cardiac, renal and hepatic disease
  • Intolerance to alcohol
  • Allergy to acarbose treatment
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00417950


Contacts
Contact: I Te Lee, MD, MS 886-4-23592525 ext 3065 itlee@vghtc.gov.tw

Locations
Taiwan
Taichung Veterans General Hospital Recruiting
Taichung, Taiwan
Contact: Wayne H Sheu, MD, PhD    886-4-23592525 ext 3068    whhsheu@vghtc.gov.tw   
Principal Investigator: Wayne H Sheu, MD, PhD         
Sub-Investigator: I Te Lee, MD, MS         
Sponsors and Collaborators
Taichung Veterans General Hospital
Tri-Service General Hospital
Investigators
Principal Investigator: Wayne H Sheu, MD, PhD Taichung Veterans General Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00417950     History of Changes
Other Study ID Numbers: 950801/C06138
First Submitted: January 1, 2007
First Posted: January 4, 2007
Last Update Posted: January 4, 2007
Last Verified: January 2007

Keywords provided by Taichung Veterans General Hospital:
diabetes
acarbose
alcohol
inflammation
oxidative stress
Mild diabetes mellitus

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Intolerance
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hyperglycemia
Acarbose
Glycoside Hydrolase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Hypoglycemic Agents
Physiological Effects of Drugs