Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00417950
Recruitment Status : Unknown
Verified January 2007 by Taichung Veterans General Hospital.
Recruitment status was:  Recruiting
First Posted : January 4, 2007
Last Update Posted : January 4, 2007
Tri-Service General Hospital
Information provided by:
Taichung Veterans General Hospital

Brief Summary:
To understand if acarbose, an alpha-glucosidase inhibitor usually for treating diabetes, will further lower post meal glucose and inflammatory state when taking together with moderate amount of alcohol during meal tolerance test in subjects with impaired glucose tolerance or mild diabetes.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus Impaired Glucose Tolerance Drug: Acarbose Not Applicable

Study Type : Interventional  (Clinical Trial)
Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : January 2007

Resource links provided by the National Library of Medicine

Drug Information available for: Acarbose
U.S. FDA Resources

Primary Outcome Measures :
  1. Postprandial hyperglycemia

Secondary Outcome Measures :
  1. Postprandial inflammatory responses
  2. Postprandial oxidative stress

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Subjects with mild diabetes without prior medications or impaired glucose tolerance

Exclusion Criteria:

  • Pregnancy
  • Recent major cardiac, renal and hepatic disease
  • Intolerance to alcohol
  • Allergy to acarbose treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00417950

Contact: I Te Lee, MD, MS 886-4-23592525 ext 3065

Taichung Veterans General Hospital Recruiting
Taichung, Taiwan
Contact: Wayne H Sheu, MD, PhD    886-4-23592525 ext 3068   
Principal Investigator: Wayne H Sheu, MD, PhD         
Sub-Investigator: I Te Lee, MD, MS         
Sponsors and Collaborators
Taichung Veterans General Hospital
Tri-Service General Hospital
Principal Investigator: Wayne H Sheu, MD, PhD Taichung Veterans General Hospital Identifier: NCT00417950     History of Changes
Other Study ID Numbers: 950801/C06138
First Posted: January 4, 2007    Key Record Dates
Last Update Posted: January 4, 2007
Last Verified: January 2007

Keywords provided by Taichung Veterans General Hospital:
oxidative stress
Mild diabetes mellitus

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Intolerance
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Glycoside Hydrolase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Hypoglycemic Agents
Physiological Effects of Drugs