Knee Malalignment and Thigh Muscle Strengthening in Individuals With Medial Knee Arthritis
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ClinicalTrials.gov Identifier: NCT00414557 |
Recruitment Status :
Completed
First Posted : December 21, 2006
Last Update Posted : December 22, 2006
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Knee Osteoarthritis | Procedure: Quadriceps strengthening | Phase 2 Phase 3 |
Although quadriceps strengthening is the cornerstone of physiotherapy management, recent evidence suggests that high quadriceps strength in patients with malaligned knees may increase OA progression.
This study investigates the effects of quadriceps strengthening on the adduction moment in patients with medial knee OA with and without malalignment. 107 participants with and without varus knee malalignment were recruited and randomised into an exercise or a control group. Participants in the exercise group were taught five quadriceps strengthening exercises by a project physiotherapist to be performed five days a week for twelve weeks at home. The exercises were:
- Quadriceps exercise over fulcrum using ankle weight
- Straight leg raise exercise using ankle weight
- Long arc knee extension exercise in sitting using ankle weight
- Knee extension exercise with isometric hold at 60° knee flexion using ankle weight
- Knee extension exercise with isometric hold at 60° knee flexion using an elastic band.
Each exercise was performed at 2x10 repetitions for the first 2 weeks and 3x10 repetitions thereafter.
Participants visited the physiotherapist 7 times at Week 1, 2, 3, 4, 5, 7 and 10. They were given the ankle weights and elastic band to bring home and instructed about the repetitions and weights to use by the physiotherapist, who also checked and progressed their exercises. The average duration of the physiotherapy sessions was 30 minutes. To monitor compliance, each participant was given an exercise instructions sheet and kept a training diary to record the exercises they had done.
The control group received no intervention.
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 107 participants |
Allocation: | Randomized |
Intervention Model: | Factorial Assignment |
Masking: | Single |
Primary Purpose: | Treatment |
Official Title: | The Effects of Knee Malalignment and Quadriceps Strengthening on the Adduction Moment in Individuals With Medial Knee Osteoarthritis |
Study Start Date : | May 2004 |
Study Completion Date : | December 2006 |

- Adduction moment
- Time points: 0 and 13 weeks
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire
- Numerical rating scales for pain
- Quadriceps and hamstrings strength
- Self-selected walking speed
- Dynamic balance using step test
- Physical function using stair climb test
- Time points: 0 and 13 weeks

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Ages Eligible for Study: | 50 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Pain in the knee
- Osteophytes on knee x-ray
- Self-reported pain on the inner aspect of the study knee
- Osteophytes in the medial compartment of the knee joint and
- Medial joint space narrowing greater than lateral joint space narrowing on x-ray
Exclusion Criteria:
- Knee surgery within the previous 6 months
- History of lower limb joint replacements
- Systemic arthritic conditions such as rheumatic or psoriatic arthritis
- Valgus knee deformity (> 5º)
- Inability to walk without the use of walking aids
- Intending to start a lower limb strengthening program in the next 3 months
- Seeking or currently receiving physiotherapy for OA knee

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00414557
Australia, Victoria | |
The University of Melbourne | |
Melbourne, Victoria, Australia, 3040 |
Principal Investigator: | Kim Bennell, PhD | University of Melbourne | |
Principal Investigator: | Rana Hinman, PhD | University of Melbourne | |
Principal Investigator: | Tim Wrigley, MSc | University of Melbourne | |
Principal Investigator: | Boon W Lim, MSc | University of Melbourne | |
Principal Investigator: | Leena Sharma, MD | Northwestern University Medical School, Chicago |
ClinicalTrials.gov Identifier: | NCT00414557 |
Other Study ID Numbers: |
040850 |
First Posted: | December 21, 2006 Key Record Dates |
Last Update Posted: | December 22, 2006 |
Last Verified: | December 2006 |
Musculoskeletal diseases Joint diseases |
Osteoarthritis Osteoarthritis, Knee Arthritis |
Joint Diseases Musculoskeletal Diseases Rheumatic Diseases |