SLV308 for Treatment of Patients With Parkinson's Disease Experiencing Motor Fluctuations
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This study is a multicenter, randomized, double blind, parallel group study of 3 months' treatment with SLV308 administered as a monotherapy in patients with advance stage PD. An open label safety extension to this study is planned as a separate protocol for patients who are willing and eligible to participate.
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Ages Eligible for Study:
30 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Diagnosis of idiopathic Parkinson's Disease,
advance stage of disease,
Modified Hoehn & Yahr stage II-IV,
presence of a recognizable 'on' and 'off' state (motor fluctuations) and stable treatment with levodopa for at least 28 days prior to randomization
'on-off' phenomena or 'yo-yoing' and/or an abrupt unpredictable loss of efficacy unrelated to the timing of L-DOPA administration,
Prevalent expression of troublesome dyskinesias during 'on' time at waking hours,
Diagnosis is unclear or a suspicion of other parkinsonian syndromes exists,