We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00395590
Recruitment Status : Unknown
Verified February 2005 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : November 3, 2006
Last Update Posted : November 3, 2006
Sponsor:
Information provided by:

Study Description
Brief Summary:
Obstructive sleep apnea is a common sleep disorder. It is known to be related with increased body mass, abdominal obesity, insulin resistance and hypertension. It is currently believed to be a feature of the metabolic syndrome. Other features of the metabolic syndrome-such as insulin resistace were found related to inflammation and inflammatory cytokines. Several polymorphisms in the genes that encode interleukin 6,inteleukin 10 and TNF-alpha have significant influence on the amounts of cytokine production. we thus hypothesize that polymorphisms related to increased pruduction are more common in subjects with OSA than in matched controls

Condition or disease
Sleep Apnea

Detailed Description:
Patients attending a sleep apnea clinic for evluation will be recruited. Patients found positive for OSA will be compared to the patients with a negative study for OSA for the prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels

Study Design

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: A Cross Sectional Study of Patients With Obstructive Sleep Apnea for Polymorphisms in Genes of Inflammatory Cytokines.
Study Start Date : November 2006
Estimated Study Completion Date : November 2007

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients attending the sleep apnea clinic for evaluation

Exclusion Criteria:

  • patients known to have inflammatory conditions
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00395590


Contacts
Contact: michal mates, MD 02-6555111 ext 55650 rheum@szmc.org.il
Contact: Gheona Altarescu

Sponsors and Collaborators
Shaare Zedek Medical Center
Investigators
Study Director: mates mates, MD Ben-Gurion University of the Negev
More Information

ClinicalTrials.gov Identifier: NCT00395590     History of Changes
Other Study ID Numbers: 5594ctil
First Posted: November 3, 2006    Key Record Dates
Last Update Posted: November 3, 2006
Last Verified: February 2005

Keywords provided by Shaare Zedek Medical Center:
OSA inflammatory cytokines, metabolic syndrome

Additional relevant MeSH terms:
Apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases