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Non Alcoholic Fatty Liver Disease in Rheumatoid Arthritis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2006 by Shaare Zedek Medical Center.
Recruitment status was:  Not yet recruiting
Information provided by:
Shaare Zedek Medical Center Identifier:
First received: October 29, 2006
Last updated: October 30, 2006
Last verified: July 2006

Rheumatoid arthritis is a chronic inflammatory systemic disease. It has a worldwide distribution and can affect all age group. The peak incidence is between fourth and sixth decade. It is more prevalent in women, and it’s prevalence in the general population in North America is between 0.2-1.5%. The etiology of RA is unknown, although clusters of the disease in families and high concordance in mono-zydotic twins support genetic predisposition. The prevalence of fatty liver disease in patients with rheumatoid arthritis is currently unknown. We wish to study the link between the two conditions by performing a son graphic imaging of the liver in a cohort of RA patients. If indeed a high prevalence of NAFLD will be found in the RA patients, further support will be landed for the link between inflammation and fatty liver disease. These findings may also have implications regarding the management and follow up of RA patients.

The validity of sonographic imaging for detection of fatty liver diseases is currently accepted: On ultrasonographic, fatty infiltration of the liver produces a diffuse increase in echogenicity as compared with that of the kidneys. Ultrasonography has a sensitivity of 89% and a specificity of 93% in detecting steatosis and sensitivity and specificity of 77% and 89% respectively in detecting increase fibrosis.

In view of all the above data, we expected to find higher prevalence of fatty liver in the patients with higher inflammation markers compare with patients with lower markers.

Condition Intervention
Arthritis, Rheumatoid Procedure: Ultrasonographic imaging

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Retrospective/Prospective

Resource links provided by NLM:

Further study details as provided by Shaare Zedek Medical Center:

Estimated Enrollment: 50
Study Start Date: November 2006
Estimated Study Completion Date: October 2008

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Rheumatoid arthritis

Exclusion Criteria:

  • Age below 18
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00394238

Contact: Ornit Cohen, Msc 0507867234

Rheumatoid Clinic Not yet recruiting
Jerusalem, Israel
Contact: Michal Mates, MD    0544727635   
Contact: Ornit Cohen, MSc    0507867234   
Principal Investigator: Michal Mates, MD         
Sponsors and Collaborators
Shaare Zedek Medical Center
Principal Investigator: Michal Mates, MD Shaare Zedek Medical Center Jerusalem
  More Information Identifier: NCT00394238     History of Changes
Other Study ID Numbers: 20174CTIL
Study First Received: October 29, 2006
Last Updated: October 30, 2006

Additional relevant MeSH terms:
Non-alcoholic Fatty Liver Disease
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Fatty Liver
Liver Diseases
Digestive System Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases processed this record on September 21, 2017